POLD4

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Polimeraza (DNK vođena), delta 4, pomoćna podjedinica
Identifikatori
Simboli	POLD4; POLDS; p12
Vanjski ID	OMIM: 611525 MGI: 1916995 HomoloGene: 10909 GeneCards: POLD4 Gene
Ontologija gena Molekulska funkcija • aktivnost DNK vođene DNK polimeraze • proteinsko vezivanje Ćelijska komponenta • nukleus • nukleoplazma Biološki proces • S faza mitotičkog ćelijskog ciklusa • mitotički ćelijski ciklus • telomerno održavanje rekombinacijom
Ortolozi
Vrsta	Čovek	Miš
Entrez	57804	69745
Ensembl	ENSG00000175482	ENSMUSG00000024854
UniProt	Q9HCU8	Q9CWP8
Ref. Sekv. (iRNK)	NM_001256870	NM_027196
Ref. Sekv. (protein)	NP_001243799	NP_081472
Lokacija (UCSC)	Chr 11: 67.12 - 67.12 Mb	Chr 19: 4.23 - 4.23 Mb
PubMed pretraga	[1]	[2]

Delta podjedinica 4 DNK polimeraze, takođe poznata kao delta podjedinica p12 DNK polimeraze, je protein koji je kod ljudi kodiran POLD4 genom.^[1] Ona je komponeneta kompleksa DNK polimeraze delta.

Reference

1. „Entrez Gene: polymerase (DNA-directed)”. 

Literatura

• Xie B, Mazloum N, Liu L, et al. (2002). „Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme.”. Biochemistry 41 (44): 13133–42. DOI:10.1021/bi0262707. PMID 12403614. 
• Selak N, Bachrati CZ, Shevelev I, et al. (2008). „The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta.”. Nucleic Acids Res. 36 (16): 5166–79. DOI:10.1093/nar/gkn498. PMC 2532730. PMID 18682526. 
• Bae SH, Bae KH, Kim JA, Seo YS (2001). „RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes.”. Nature 412 (6845): 456–61. DOI:10.1038/35086609. PMID 11473323. 
• Matsumoto Y, Kim K, Hurwitz J, et al. (1999). „Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins.”. J. Biol. Chem. 274 (47): 33703–8. DOI:10.1074/jbc.274.47.33703. PMID 10559261. 
• Liu G, Warbrick E (2006). „The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins.”. Biochem. Biophys. Res. Commun. 349 (1): 360–6. DOI:10.1016/j.bbrc.2006.08.049. PMID 16934752. 
• Tsurimoto T, Shinozaki A, Yano M, et al. (2005). „Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta.”. Genes Cells 10 (1): 13–22. DOI:10.1111/j.1365-2443.2004.00812.x. PMID 15670210. 
• Wood RD, Shivji MK (1997). „Which DNA polymerases are used for DNA-repair in eukaryotes?”. Carcinogenesis 18 (4): 605–10. DOI:10.1093/carcin/18.4.605. PMID 9111189. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Huang QM, Akashi T, Masuda Y, et al. (2010). „Roles of POLD4, smallest subunit of DNA polymerase delta, in nuclear structures and genomic stability of human cells.”. Biochem. Biophys. Res. Commun. 391 (1): 542–6. DOI:10.1016/j.bbrc.2009.11.094. PMID 19931513. 
• Li H, Xie B, Zhou Y, et al. (2006). „Functional roles of p12, the fourth subunit of human DNA polymerase delta.”. J. Biol. Chem. 281 (21): 14748–55. DOI:10.1074/jbc.M600322200. PMID 16510448. 
• Liu L, Mo J, Rodriguez-Belmonte EM, Lee MY (2000). „Identification of a fourth subunit of mammalian DNA polymerase delta.”. J. Biol. Chem. 275 (25): 18739–44. DOI:10.1074/jbc.M001217200. PMID 10751307.