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RARA
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1DKF, 1DSZ, 3A9E, 3KMR, 3KMZ, 4DQM, 5K13
معین‌کننده‌ها
نام‌های دیگر	RARA, NR1B1, RAR, retinoic acid receptor alpha, RARalpha
شناسه‌های بیرونی	OMIM: 180240 MGI: 97856 HomoloGene: 20262 GeneCards: RARA
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۱ (موش)
پایان	98,865,768 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• retinoic acid binding; • GO:0001106 transcription corepressor activity; • protein domain specific binding; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • GO:0038050، GO:0004886، GO:0038051 nuclear receptor activity; • mRNA 5'-UTR binding; • signaling receptor binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • retinoic acid-responsive element binding; • transcription factor binding; • metal ion binding; • steroid hormone receptor activity; • enzyme binding; • zinc ion binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • DNA binding; • sequence-specific DNA binding; • GO:0001105 transcription coactivator activity; • protein kinase A binding; • protein kinase B binding; • translation repressor activity, mRNA regulatory element binding; • alpha-actinin binding; • protein heterodimerization activity; • chromatin DNA binding; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • histone deacetylase binding; • GO:0000975 transcription cis-regulatory region binding; • nuclear receptor coactivator activity; • signaling receptor activity;
ترکیبات سلولی	• سیتوپلاسم; • actin cytoskeleton; • perinuclear region of cytoplasm; • neuron projection; • هسته یاخته; • cell surface; • نوکلئوپلاسم; • soma; • دندریت; • سیتوزول; • RNA polymerase II transcription regulator complex;
فرایند زیستی	• growth plate cartilage development; • germ cell development; • cellular response to retinoic acid; • ureteric bud development; • positive regulation of interleukin-5 production; • prostate gland development; • limb development; • apoptotic cell clearance; • chondroblast differentiation; • regulation of granulocyte differentiation; • protein phosphorylation; • response to vitamin A; • face development; • اسپرماتوژنز; • response to ethanol; • negative regulation of cell population proliferation; • steroid hormone mediated signaling pathway; • regulation of apoptotic process; • response to cytokine; • negative regulation of translation; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of cell differentiation; • negative regulation of gene expression; • transcription, DNA-templated; • cellular response to estrogen stimulus; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of cell cycle; • regulation of myelination; • positive regulation of neuron differentiation; • negative regulation of tumor necrosis factor production; • transcription initiation from RNA polymerase II promoter; • trachea cartilage development; • glandular epithelial cell development; • male gonad development; • negative regulation of cartilage development; • response to retinoic acid; • negative regulation of granulocyte differentiation; • multicellular organism growth; • female pregnancy; • negative regulation of apoptotic process; • GO:1901227 negative regulation of transcription by RNA polymerase II; • positive regulation of interleukin-4 production; • regulation of synaptic plasticity; • outflow tract septum morphogenesis; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of interferon-gamma production; • response to estradiol; • negative regulation of translational initiation; • embryonic camera-type eye development; • positive regulation of interleukin-13 production; • neural tube closure; • positive regulation of binding; • retinoic acid receptor signaling pathway; • GO:1901313 positive regulation of gene expression; • Sertoli cell fate commitment; • positive regulation of cell population proliferation; • positive regulation of T-helper 2 cell differentiation; • ventricular cardiac muscle cell differentiation; • liver development; • cellular response to lipopolysaccharide; • bone development; • hippocampus development; • GO:0072468 ورارسانی پیام; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • multicellular organism development; • hormone-mediated signaling pathway; • دگرگونی یاخته‌; • response to lipid; • gland development; • bone morphogenesis; • epithelium development;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5914
	19401
	ENSG00000131759
	ENSMUSG00000037992
	P10276; Q6I9R7
	P11416
	NM_000964، NM_001024809، NM_001033603، NM_001145301، NM_001145302، XM_005257552، XM_005257553، XM_005257554، XM_011525095، XM_047436506، XM_047436507، XM_047436508 XM_011525096، NM_000964، NM_001024809، NM_001033603، NM_001145301، NM_001145302، XM_005257552، XM_005257553، XM_005257554، XM_011525095، XM_047436506، XM_047436507، XM_047436508
	NM_001177302، NM_001177303، NM_009024، XM_006532592، XM_006532593، XM_006532597، NM_001361954، XM_030245701، XM_030245702 NM_001176528، NM_001177302، NM_001177303، NM_009024، XM_006532592، XM_006532593، XM_006532597، NM_001361954، XM_030245701، XM_030245702
	NP_001019980، NP_001138773، NP_001138774، XP_005257609، XP_005257610، XP_005257611، XP_011523397، XP_011523398، XP_016880409 NP_000955، NP_001019980، NP_001138773، NP_001138774، XP_005257609، XP_005257610، XP_005257611، XP_011523397، XP_011523398، XP_016880409; NP_001138773.1، XP_005257610.1، XP_005257611.1، XP_011523397.1 NP_000955.1، NP_001138773.1، XP_005257610.1، XP_005257611.1، XP_011523397.1
	NP_001170773، NP_001170774، NP_033050، XP_006532655، XP_006532656، XP_006532660، NP_001348883، XP_030101561، XP_030101562 NP_001169999، NP_001170773، NP_001170774، NP_033050، XP_006532655، XP_006532656، XP_006532660، NP_001348883، XP_030101561، XP_030101562
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

گیرنده آلفای رتینوئیک اسید (انگلیسی: Retinoic acid receptor alpha) یا به اختصار RAR-α، یک پروتئین است که در انسان توسط ژن «RARA» کُدگذاری می‌شود.^[۴]^[۵]

این پروتئین، یک گیرنده هسته‌ای، و یکی از انواع گیرنده‌های رتینوئیک اسید است.

این مولکول با ژن ساعت^[۶] و همچنین پروتئین‌های ZBTB16^[۷] و C-Src^[۸]^[۹] تعامل پروتئین-پروتئین دارد.

اهمیت بالینی

جابجایی‌های کروموزومی که منجر به تغییر مکان جایگاه ژنی این پروتئین گردد، به ویژه اگر از نوع t(15,17)(q21;q22) باشد در بروز لوسمی پرومیلوسیتیک حاد نقش دارد.^[۱۰]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000037992 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Giguere V, Ong ES, Segui P, Evans RM (1987). "Identification of a receptor for the morphogen retinoic acid". Nature. 330 (6149): 624–9. doi:10.1038/330624a0. PMID 2825036.
↑ Anderson LA, Friedman L, Osborne-Lawrence S, Lynch E, Weissenbach J, Bowcock A, King MC (September 1993). "High-density genetic map of the BRCA1 region of chromosome 17q12-q21". Genomics. 17 (3): 618–23. doi:10.1006/geno.1993.1381. PMID 8244378.
↑ McNamara P, Seo SB, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA (June 2001). "Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock". Cell. 105 (7): 877–89. doi:10.1016/S0092-8674(01)00401-9. PMID 11439184.
↑ Martin PJ, Delmotte MH, Formstecher P, Lefebvre P (September 2003). "PLZF is a negative regulator of retinoic acid receptor transcriptional activity". Nucl. Recept. 1 (1): 6. doi:10.1186/1478-1336-1-6. PMC 212040. PMID 14521715.
↑ Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW (September 1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.
↑ He B, Wilson EM (March 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. 23 (6): 2135–50. doi:10.1128/MCB.23.6.2135-2150.2003. PMC 149467. PMID 12612084.
↑ Vitoux D, Nasr R, de The H (2007). "Acute promyelocytic leukemia: new issues on pathogenesis and treatment response". Int. J. Biochem. Cell Biol. 39 (6): 1063–70. doi:10.1016/j.biocel.2007.01.028. PMID 17468032.

مشارکت‌کنندگان ویکی‌پدیا. «Retinoic acid receptor alpha». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۳ فوریه ۲۰۲۰.

برای مطالعهٔ بیشتر

Petkovich M, Brand NJ, Krust A, Chambon P (1988). "A human retinoic acid receptor which belongs to the family of nuclear receptors". Nature. 330 (6147): 444–50. doi:10.1038/330444a0. PMID 2825025.
Sirulnik A, Melnick A, Zelent A, Licht JD (2003). "Molecular pathogenesis of acute promyelocytic leukaemia and APL variants". Best Pract Res Clin Haematol. 16 (3): 387–408. doi:10.1016/S1521-6926(03)00062-8. PMID 12935958.
Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM (1992). "Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling". Nature. 355 (6359): 446–9. doi:10.1038/355446a0. PMC 6159885. PMID 1310351.
Kastner P, Perez A, Lutz Y, Rochette-Egly C, Gaub MP, Durand B, Lanotte M, Berger R, Chambon P (1992). "Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins". EMBO J. 11 (2): 629–42. PMC 556495. PMID 1311253.
Baniahmad A, Köhne AC, Renkawitz R (1992). "A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor". EMBO J. 11 (3): 1015–23. PMC 556542. PMID 1347744.
de Thé H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A (1991). "The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR". Cell. 66 (4): 675–84. doi:10.1016/0092-8674(91)90113-D. PMID 1652369.
de Thé H, Chomienne C, Lanotte M, Degos L, Dejean A (1990). "The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus". Nature. 347 (6293): 558–61. doi:10.1038/347558a0. PMID 2170850.
Brand NJ, Petkovich M, Chambon P (1990). "Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-alpha)". Nucleic Acids Res. 18 (23): 6799–806. doi:10.1093/nar/18.23.6799. PMC 332734. PMID 2175878.
Borrow J, Goddard AD, Sheer D, Solomon E (1990). "Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17". Science. 249 (4976): 1577–80. doi:10.1126/science.2218500. PMID 2218500.
Arveiler B, Petkovich M, Mandel JL, Chambon P (1988). "A PstI RFLP for the human retinoic acid receptor in 17q21". Nucleic Acids Res. 16 (13): 6252. doi:10.1093/nar/16.13.6252. PMC 336887. PMID 2899875.
Chen JD, Evans RM (1995). "A transcriptional co-repressor that interacts with nuclear hormone receptors". Nature. 377 (6548): 454–7. doi:10.1038/377454a0. PMID 7566127.
Fisher GJ, Talwar HS, Xiao JH, Datta SC, Reddy AP, Gaub MP, Rochette-Egly C, Chambon P, Voorhees JJ (1994). "Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin". J. Biol. Chem. 269 (32): 20629–35. PMID 8051161.
Chen Z, Guidez F, Rousselot P, Agadir A, Chen SJ, Wang ZY, Degos L, Zelent A, Waxman S, Chomienne C (1994). "PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors". Proc. Natl. Acad. Sci. U.S.A. 91 (3): 1178–82. doi:10.1073/pnas.91.3.1178. PMC 521477. PMID 8302850.
Redner RL, Rush EA, Faas S, Rudert WA, Corey SJ (1996). "The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion". Blood. 87 (3): 882–6. PMID 8562957.
Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin SC, Heyman RA, Rose DW, Glass CK, Rosenfeld MG (1996). "A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors". Cell. 85 (3): 403–14. doi:10.1016/S0092-8674(00)81118-6. PMID 8616895.
Liu W, Hellman P, Li Q, Yu WR, Juhlin C, Nordlinder H, Rollman O, Akerström G, Törmä H, Melhus H (1996). "Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells". Biochem. Biophys. Res. Commun. 229 (3): 922–9. doi:10.1006/bbrc.1996.1903. PMID 9005841.
Thénot S, Henriquet C, Rochefort H, Cavaillès V (1997). "Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1". J. Biol. Chem. 272 (18): 12062–8. doi:10.1074/jbc.272.18.12062. PMID 9115274.