Talk:HERG

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The name

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This sounds fake to me. Ether-a-go-go? Anyone care to explain this ridiculous-sounding name? —Keenan Pepper 10:00, 11 August 2005 (UTC)[reply]__DTELLIPSISBUTTON__{"threadItem":{"timestamp":"2005-08-11T10:00:00.000Z","author":"Keenan Pepper","type":"comment","level":1,"id":"c-Keenan_Pepper-2005-08-11T10:00:00.000Z-The_name","replies":[]}}-->

No, its quite factual. The hERG channel was identified in Drosophila flies and named so because when they were anaesthetised with ether, their legs started shaking.

bignoter 11:20, August 16, 2005 (UTC)

D. melanogaster gene ether a go-go , abbreviated as eag, encodes a product with voltage-gated potassium channel activity involved in courtship behavior. Mutants shake their legs under ether anesthesia. HERG channel, or KCNH2, is encoded by the eag-related gene, they share some characteristic but are two distinct protein.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=32428

gentile 3:42, September 11, 2005

I am currently adding to this page; I have left some minor grammar errors due to lack of time tonight. While I understand the low priority for ion channels in general, I suspect that because of hERG's central role in virtually all drug discovery programmes for human pharmaceuticals, hERG may be somewhat more important to wikipedia than other channels. Relleh22hctac (talk) 03:09, 2 February 2009 (UTC)[reply]__DTELLIPSISBUTTON__{"threadItem":{"timestamp":"2009-02-02T03:09:00.000Z","author":"Relleh22hctac","type":"comment","level":1,"id":"c-Relleh22hctac-2009-02-02T03:09:00.000Z-The_name","replies":[]}}-->

We should fix the name, there is no french accent on the "a". Aytrus (talk) 15:36, 30 May 2010 (UTC)[reply]__DTELLIPSISBUTTON__{"threadItem":{"timestamp":"2010-05-30T15:36:00.000Z","author":"Aytrus","type":"comment","level":1,"id":"c-Aytrus-2010-05-30T15:36:00.000Z-The_name","replies":[]}}-->

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Side helix

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What is the "side helix" mentioned in the 'structure' section? I have never heard of it; does this refer to the alpha helical region in the turret or in the cyclic nucleotide binding domain? I am tempted to delete "side helix". Relleh22hctac (talk) 03:09, 2 February 2009 (UTC)[reply]__DTELLIPSISBUTTON__{"threadItem":{"timestamp":"2009-02-02T03:09:00.000Z","author":"Relleh22hctac","type":"comment","level":1,"id":"c-Relleh22hctac-2009-02-02T03:09:00.000Z-Side_helix","replies":["c-Boghog2-2009-02-02T06:42:00.000Z-Relleh22hctac-2009-02-02T03:09:00.000Z","c-Dpryan-2009-02-02T22:27:00.000Z-Relleh22hctac-2009-02-02T03:09:00.000Z"]}}-->

That puzzled me too. After searching PubMed and Google, I cannot find any source to document the use of the term "side helx" in the context of the hERG structure. Therefore I have deleted it. (BTW: excellent edits Relleh22hctac!). Cheers. Boghog2 (talk) 06:42, 2 February 2009 (UTC)[reply]__DTELLIPSISBUTTON__{"threadItem":{"timestamp":"2009-02-02T06:42:00.000Z","author":"Boghog2","type":"comment","level":2,"id":"c-Boghog2-2009-02-02T06:42:00.000Z-Relleh22hctac-2009-02-02T03:09:00.000Z","replies":[]}}-->

Perhaps what was really meant was beta subunit (minK)? That or it was a typo for slide helix. Either way, Boghog2's edits seem an appropriate fix. --Dpryan (talk) 22:27, 2 February 2009 (UTC)[reply]__DTELLIPSISBUTTON__{"threadItem":{"timestamp":"2009-02-02T22:27:00.000Z","author":"Dpryan","type":"comment","level":2,"id":"c-Dpryan-2009-02-02T22:27:00.000Z-Relleh22hctac-2009-02-02T03:09:00.000Z","replies":[]}}-->

Extra details that need to be added

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• The relationship between hERG and early afterdepolarisations
• The unusual length of the turret

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Suggested subject headings that may ultimately be useful for ion channels

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• Basic Features (why is it notable)
• Biological Functions
  • In the Action Potential of Excitable Cells
  • In other cell types
• Structure
• Mechanism of Action
• Gating: How the Channel
• Selective Permeability
• Diseases of
• Location
  • Cells where hERG is found: Expression profile
  • Animals that have hERG
  • Diversity
  • Evolutionary Relationship to other Ion Channels
  • Classification
• History
• In Art and Popular Culture (probably not so much for hERG yet)

Relleh22hctac (talk) 10:10, 13 February 2009 (UTC)[reply]__DTELLIPSISBUTTON__{"threadItem":{"timestamp":"2009-02-13T10:10:00.000Z","author":"Relleh22hctac","type":"comment","level":1,"id":"c-Relleh22hctac-2009-02-13T10:10:00.000Z-Suggested_subject_headings_that_may_ultimately_be_useful_for_ion_channels","replies":[]}}-->

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Image

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Use the improved image: . — Preceding unsigned comment added by JVertrees (talk • contribs) 22:37, 19 December 2012 (UTC)[reply]__DTELLIPSISBUTTON__{"threadItem":{"timestamp":"2012-12-19T22:37:00.000Z","author":"JVertrees","type":"comment","level":1,"id":"c-JVertrees-2012-12-19T22:37:00.000Z-Image","replies":[]}}-->

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External links modified

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Structure

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Full-length cryo-electron microscopy structures of hERG has been available since 2017: https://doi.org/10.1016/j.cell.2017.03.048 163.1.63.21 (talk) 19:33, 8 February 2023 (UTC)[reply]__DTELLIPSISBUTTON__{"threadItem":{"timestamp":"20230208193300","author":"163.1.63.21","type":"comment","level":1,"id":"c-163.1.63.21-20230208193300-Structure","replies":[]}}-->