List of investigational sleep drugs
This is a list of investigational sleep drugs , or drugs for the treatment of sleep disorders that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.
Insomnia
GABAA receptor potentiators
Orexin receptor antagonists
Seltorexant (MIN-202, JNJ,42847922, JNJ-922) – selective OX2 receptor antagonist [4]
Vornorexant (ORN-0829, TS-142) – dual OX1 and OX2 receptor antagonist [5]
Melatonin receptor agonists
Nociceptin receptor agonists
Hypersomnia/narcolepsy
Orexin receptor agonists
Monoaminergics
GHB receptor agonists
GABAA receptor inhibitors
See also
References
^ a b "Takeda" . www.ox2rsparkleprogram.com . Retrieved 2019-11-15 .
GABAA receptor positive modulators
Others: Alcohols (e.g., ethchlorvynol , amylene hydrate , ethanol )
Barbiturates (e.g., amobarbital , pentobarbital , phenobarbital , secobarbital )
Bromides (e.g., potassium bromide , sodium bromide )
Carbamates (e.g., meprobamate )
Chloral hydrate
Clomethiazole
Kava
Neurosteroids (e.g., progesterone , zuranolone † )
Paraldehyde
Piperidinediones (e.g., glutethimide )
Quinazolinones (e.g., methaqualone )
Sulfonmethane
Valerian
Antihistamines (H1 receptor inverse agonists )Orexin receptor antagonists Melatonin receptor agonists Miscellaneous
Antipsychotics (e.g., quetiapine , olanzapine , risperidone , chlorpromazine )
Ashwagandha
Benzoctamine
Cannabinoids (e.g., cannabis , dronabinol (THC ) , nabilone )
Chamomile
Fenadiazole
Gabapentinoids (e.g., gabapentin , pregabalin , phenibut )
Hops
Lavender
Menthyl isovalerate
Niaprazine
Opioids (e.g., hydrocodone , oxycodone , morphine )
Passion flower
Scopolamine
Serotonin precursors (tryptophan , 5-HTP Tooltip 5-hydroxytryptophan )
Sodium oxybate (GHB )
Sympatholytics (e.g., clonidine , guanfacine , prazosin )
Theanine
Trazodone
Tricyclic antidepressants (e.g., amitriptyline , doxepin , trimipramine )
Tetracyclic antidepressants (e.g., mirtazapine )
Valnoctamide