Α-PCYP

Not to be confused with PCPy.

α-PCyP

Legal status
Legal status	CA: Schedule I DE: NpSG (Industrial and scientific use only) UK: Under Psychoactive Substances Act US: Unscheduled Illegal in Virginia[1]
Identifiers
IUPAC name 2-cyclohexyl-1-phenyl-2-(pyrrolidin-1-yl)ethanone
CAS Number	1803168-11-7^Y
PubChem CID	155884437
UNII	PJ2S9WH4A2
CompTox Dashboard (EPA)	DTXSID501337041
Chemical and physical data
Formula	C18H25NO
Molar mass	271.404 g·mol^−1
3D model (JSmol)	Interactive image
SMILES O=C(C(C1CCCCC1)N2CCCC2)c3ccccc3
InChI InChI=1S/C18H25NO/c20-18(16-11-5-2-6-12-16)17(19-13-7-8-14-19)15-9-3-1-4-10-15/h2,5-6,11-12,15,17H,1,3-4,7-10,13-14H2 Key:FKEHRWJWTWDTDB-UHFFFAOYSA-N

α-PCyP (α-PyrrolidinoCyclohexanoPhenone) is a stimulant drug of the cathinone class that has been sold online as a designer drug. In a series of alpha-substituted pyrrolidinyl cathinone derivatives developed in 2015, the alpha-cyclopentyl derivative was found to have around the same potency in vitro as an inhibitor of the dopamine transporter as the alpha-propyl derivative α-PVP, while the alpha-cyclohexyl derivative α-PCyP was around twice as strong.^[2][3][4]

See also

• PCPy
• Picilorex
• α-PHP
• α-PHiP
• Alpha-D2PV
• βk-Ephenidine
• Diphenidine
• Indapyrophenidone
• UWA-101
• Zylofuramine

References

1. "§ 54.1-3446. Schedule I." Virginia Law. Retrieved 14 September 2023.
2. Kolanos R, Sakloth F, Jain AD, Partilla JS, Baumann MH, Glennon RA (October 2015). "Structural Modification of the Designer Stimulant α-Pyrrolidinovalerophenone (α-PVP) Influences Potency at Dopamine Transporters". ACS Chemical Neuroscience. 6 (10): 1726–31. doi:10.1021/acschemneuro.5b00160. PMC 5349767. PMID 26217965.
3. Glennon RA, Dukat M (2016). "Structure-Activity Relationships of Synthetic Cathinones". Current Topics in Behavioral Neurosciences. 32: 19–47. doi:10.1007/7854_2016_41. ISBN 978-3-319-52442-9. PMC 5818155. PMID 27830576.
4. Baumann MH, Walters HM, Niello M, Sitte HH (2018). "Neuropharmacology of Synthetic Cathinones". New Psychoactive Substances. Handbook of Experimental Pharmacology. Vol. 252. pp. 113–142. doi:10.1007/164_2018_178. ISBN 978-3-030-10560-0. PMC 7257813. PMID 30406443.