Bromisoval
Chemical compound
Bromisoval (INN ), commonly known as bromovalerylurea , is a hypnotic and sedative of the bromoureide group discovered by Knoll in 1907 and patented in 1909.[ 1] It is marketed over the counter in Asia under various trade names (such as Brovarin [ 2] ), usually in combination with nonsteroidal anti-inflammatory drugs .
Chronic use of bromisoval has been associated with bromine poisoning.[ 3] [ 4] [ 5] [ 6]
Bromisoval can be prepared by bromination of isovaleric acid by the Hell-Volhard-Zelinsky reaction followed by reaction with urea .
See also
References
^
US patent 914518 , Saam, E., "Alpha-halogen-isovaleryl-urea and process of making the same", issued 1909-03-09, assigned to Knoll
^ "Bromisoval" . International . Drugs.com.
^ Hashida, H.; Honda, T.; Morimoto, H.; Aibara, Y. (2001). "市販鎮痛剤常用量の服用による慢性ブロム中毒の1例" [A case of chronic bromvalerylurea intoxication due to habitual use of commercially available nonsteroidal anti-inflammatory drugs presenting an indefinite hyperchloremia] (pdf) . Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics (in Japanese). 38 (5): 700–703. doi :10.3143/geriatrics.38.700 . ISSN 0300-9173 . PMID 11605223 .
^ Kawakami, T.; Takiyama, Y.; Yanaka, I.; Taguchi, T.; Tanaka, Y.; Nishizawa, M.; Nakano, I. (1998). "Chronic bromvalerylurea intoxication: Dystonic posture and cerebellar ataxia due to nonsteroidal anti-inflammatory drug abuse" (pdf) . Internal Medicine . 37 (9). Tokyo, Japan: 788–791. doi :10.2169/internalmedicine.37.788 . PMID 9804091 .
^ Wang, Y. -T.; Yang, S. Y.; Wu, V. C.; Wu, K. D.; Fang, C. C. (2005). "Pseudohyperchloraemia due to bromvalerylurea abuse" . Nephrology Dialysis Transplantation . 20 (8): 1767–1768. doi :10.1093/ndt/gfh945 . PMID 15972320 .
^ Arai, A.; Sato, M.; Hozumi, I.; Matsubara, N.; Tanaka, K.; Soma, Y.; Adachi, T.; Tsuji, S. (1997). "Cerebellar Ataxia and Peripheral Neuropathy due to Chronic Bromvalerylurea Poisoning" (pdf) . Internal Medicine . 36 (10). Tokyo, Japan: 742–746. doi :10.2169/internalmedicine.36.742 . PMID 9372340 .
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