HDAC1

HDAC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BKX, 5ICN
Identifiers
Aliases	HDAC1, GON-10, HD1, RPD3, RPD3L1, histone deacetylase 1, KDAC1
External IDs	OMIM: 601241; MGI: 108086; HomoloGene: 68426; GeneCards: HDAC1; OMA:HDAC1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.2-p35.1 Start 32,292,083 bp[1] End 32,333,635 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.2|4 63.26 cM Start 129,409,897 bp[2] End 129,436,506 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of colon mucosa of sigmoid colon mucosa of transverse colon epithelium of nasopharynx rectum lymph node pylorus right uterine tube cecum gums Top expressed in tail of embryo genital tubercle morula ventricular zone bone marrow yolk sac thymus embryo blastocyst placenta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding NAD-dependent histone deacetylase activity (H3-K14 specific) transcription corepressor activity histone deacetylase activity protein N-terminus binding DNA-binding transcription factor activity protein deacetylase activity histone deacetylase binding transcription cis-regulatory region binding NF-kappaB binding deacetylase activity protein binding nucleosomal DNA binding enzyme binding hydrolase activity core promoter sequence-specific DNA binding p53 binding transcription factor binding RNA polymerase II core promoter sequence-specific DNA binding DNA binding chromatin binding Krueppel-associated box domain binding E-box binding promoter-specific chromatin binding Cellular component cytoplasm NuRD complex cytosol histone deacetylase complex Sin3 complex nucleoplasm nucleus chromatin heterochromatin transcription regulator complex transcription repressor complex protein-containing complex soma Sin3-type complex Biological process hair follicle placode formation epidermal cell differentiation chromatin remodeling regulation of transcription, DNA-templated rhythmic process negative regulation of androgen receptor signaling pathway embryonic digit morphogenesis negative regulation of apoptotic process blood coagulation negative regulation of transcription by RNA polymerase II eyelid development in camera-type eye circadian regulation of gene expression negative regulation of gene expression positive regulation of transcription, DNA-templated odontogenesis of dentin-containing tooth protein deacetylation histone H4 deacetylation fungiform papilla formation negative regulation of myotube differentiation viral process histone deacetylation negative regulation of canonical Wnt signaling pathway positive regulation of transcription by RNA polymerase II transcription, DNA-templated regulation of signal transduction by p53 class mediator DNA methylation-dependent heterochromatin assembly beta-catenin-TCF complex assembly chromatin organization positive regulation of cell population proliferation negative regulation of transcription, DNA-templated histone H3 deacetylation regulation of megakaryocyte differentiation regulation of transcription by RNA polymerase II endoderm development circadian rhythm hippocampus development neuron differentiation negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of oligodendrocyte differentiation regulation of endopeptidase activity regulation of amyloid-beta clearance negative regulation of intrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3065 433759 Ensembl ENSG00000116478 ENSMUSG00000028800 UniProt Q13547 O09106 RefSeq (mRNA) NM_004964 NM_008228 RefSeq (protein) NP_004955 NP_032254 Location (UCSC) Chr 1: 32.29 – 32.33 Mb Chr 4: 129.41 – 129.44 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.^[5]

Function

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.^[6]

Interactions

HDAC1 has been shown to interact with:

• Androgen receptor,^[7]
• BCL6,^[8][9]
• BTG2,^[10][11]
• BUB1B,^[12]
• BUB1,^[12]
• BUB3,^[12]
• CBFA2T3,^[13][14]
• CDC20,^[12]
• CDH1,^[12]
• CHD3,^[15][16]
• CHD4,^[15][17][18]
• COUP-TFII,^[19]
• CTBP1,^[20][21][22]
• DDX17,^[23]
• DDX5,^[23]
• DNMT3A,^[24]
• DNMT3L,^[25][26]
• Death-associated protein 6,^[27]
• EED,^[28]
• EVI1,^[29][30]
• EZH2,^[28]
• FKBP3,^[31]
• GATA1,^[32]
• HMG20B,^[33]
• HSPA4,^[34]
• HUS1,^[35]
• Histone deacetylase 2,^{[15][17][28][33][34][36][37][38][39][40][41][42][43]}
• Homeobox protein TGIF1,^[20][44]
• Host cell factor C1,^[45]
• IFRD1,^[46]
• IKZF1,^[47][48]
• ING1,^[16][49]
• MBD3,^[41][50][51]
• MIER1,^[52]
• MLL,^[53]
• MTA1,^[17][54]
• MTA2,^{[17][41][55][56]}
• Mad1,^[12]
• Mdm2,^[57]
• Methyl-CpG-binding domain protein 2,^[41][58][59]
• Mothers against decapentaplegic homolog 2,^[60]
• MyoD,^[61][62]
• NFKB1,^[63]
• Nuclear receptor co-repressor 2,^[36][64]
• P21,^[65]
• PCNA,^[66]
• PHF21A,^[33][67]
• Prohibitin,^[68][69]
• Promyelocytic leukemia protein,^[70][71]
• RAD9A,^[35]
• RBBP4,^{[17][18][41][42][43][55][58][72][73][74][75]}
• RBBP7,^{[17][41][43][58]}
• RCOR1,^[33][55]
• RELA,^[40][63][76]
• RFC1,^[77]
• Retinoblastoma protein,^{[61][69][78][79][80][81][82]}
• Retinoblastoma-like protein 1,^[78][79]
• Retinoblastoma-like protein 2,^[78][83]
• SAP30,^{[16][41][84][85][86][87]}
• SATB1,^[56]
• SIN3A,^{[15][16][17][18][41][42][55][56][72][73][88][89][90][91]}
• SIN3B,^[41][47]
• SPEN,^[92]
• SUDS3,^[88][93]
• SUV39H1,^[94]
• Sp1 transcription factor,^{[73][95][96][97]}
• TOP2A,^[98][99]
• TOP2B,^[98][99] and
• Zinc finger and BTB domain-containing protein 16.^{[8][100][101]}

See also

• Histone deacetylase
• Histone deacetylase inhibitor

References

1. GRCh38: Ensembl release 89: ENSG00000116478 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028800 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Taunton J, Hassig CA, Schreiber SL (April 1996). "A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p". Science. 272 (5260). New York, N.Y.: 408–411. Bibcode:1996Sci...272..408T. doi:10.1126/science.272.5260.408. PMID 8602529. S2CID 25717734.
6. "Entrez Gene: HDAC1 histone deacetylase 1".
7. Gaughan L, Logan IR, Cook S, Neal DE, Robson CN (July 2002). "Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor". The Journal of Biological Chemistry. 277 (29): 25904–25913. doi:10.1074/jbc.M203423200. PMID 11994312.
8. David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene. 16 (19): 2549–2556. doi:10.1038/sj.onc.1202043. PMID 9627120. S2CID 655636.
9. Deltour S, Guerardel C, Leprince D (December 1999). "Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B". Proceedings of the National Academy of Sciences of the United States of America. 96 (26): 14831–14836. Bibcode:1999PNAS...9614831D. doi:10.1073/pnas.96.26.14831. PMC 24733. PMID 10611298.
10. Farioli-Vecchioli S, Tanori M, Micheli L, Mancuso M, Leonardi L, Saran A, et al. (July 2007). "Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3". FASEB Journal. 21 (9): 2215–2225. doi:10.1096/fj.06-7548com. PMID 17371797. S2CID 4974360.
11. Micheli L, D'Andrea G, Leonardi L, Tirone F (July 2017). "HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progression and Cyclin D1 Expression" (PDF). Journal of Cellular Physiology. 232 (7): 1696–1707. doi:10.1002/jcp.25467. PMID 27333946. S2CID 4070837.
12. Yoon YM, Baek KH, Jeong SJ, Shin HJ, Ha GH, Jeon AH, et al. (September 2004). "WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase". FEBS Letters. 575 (1–3): 23–29. Bibcode:2004FEBSL.575...23Y. doi:10.1016/j.febslet.2004.07.089. PMID 15388328. S2CID 21762011.
13. Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, et al. (September 2002). "The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies". Oncogene. 21 (43): 6703–6712. doi:10.1038/sj.onc.1205882. PMID 12242670. S2CID 19634011.
14. Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, et al. (October 2001). "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain". Molecular and Cellular Biology. 21 (19): 6470–6483. doi:10.1128/mcb.21.19.6470-6483.2001. PMC 99794. PMID 11533236.
15. Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL (October 1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature. 395 (6705): 917–921. Bibcode:1998Natur.395..917T. doi:10.1038/27699. PMID 9804427. S2CID 4355885.
16. Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (February 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Molecular and Cellular Biology. 22 (3): 835–848. doi:10.1128/mcb.22.3.835-848.2002. PMC 133546. PMID 11784859.
17. Yao YL, Yang WM (October 2003). "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity". The Journal of Biological Chemistry. 278 (43): 42560–42568. doi:10.1074/jbc.M302955200. PMID 12920132.
18. Grozinger CM, Hassig CA, Schreiber SL (April 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 4868–4873. Bibcode:1999PNAS...96.4868G. doi:10.1073/pnas.96.9.4868. PMC 21783. PMID 10220385.
19. Smirnov DA, Hou S, Ricciardi RP (March 2000). "Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription". Virology. 268 (2): 319–328. doi:10.1006/viro.1999.0181. PMID 10704340.
20. Melhuish TA, Wotton D (December 2000). "The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF". The Journal of Biological Chemistry. 275 (50): 39762–39766. doi:10.1074/jbc.C000416200. PMID 10995736.
21. Zhang CL, McKinsey TA, Lu JR, Olson EN (January 2001). "Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor". The Journal of Biological Chemistry. 276 (1): 35–39. doi:10.1074/jbc.M007364200. PMID 11022042.
22. Sundqvist A, Sollerbrant K, Svensson C (June 1998). "The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex". FEBS Letters. 429 (2): 183–188. Bibcode:1998FEBSL.429..183S. doi:10.1016/s0014-5793(98)00588-2. PMID 9650586. S2CID 20660291.
23. Wilson BJ, Bates GJ, Nicol SM, Gregory DJ, Perkins ND, Fuller-Pace FV (August 2004). "The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner". BMC Molecular Biology. 5: 11. doi:10.1186/1471-2199-5-11. PMC 514542. PMID 15298701.
24. Fuks F, Burgers WA, Godin N, Kasai M, Kouzarides T (May 2001). "Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription". The EMBO Journal. 20 (10): 2536–2544. doi:10.1093/emboj/20.10.2536. PMC 125250. PMID 11350943.
25. Aapola U, Liiv I, Peterson P (August 2002). "Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity". Nucleic Acids Research. 30 (16): 3602–3608. doi:10.1093/nar/gkf474. PMC 134241. PMID 12177302.
26. Deplus R, Brenner C, Burgers WA, Putmans P, Kouzarides T, de Launoit Y, et al. (September 2002). "Dnmt3L is a transcriptional repressor that recruits histone deacetylase". Nucleic Acids Research. 30 (17): 3831–3838. doi:10.1093/nar/gkf509. PMC 137431. PMID 12202768.
27. Li H, Leo C, Zhu J, Wu X, O'Neil J, Park EJ, et al. (March 2000). "Sequestration and inhibition of Daxx-mediated transcriptional repression by PML". Molecular and Cellular Biology. 20 (5): 1784–1796. doi:10.1128/mcb.20.5.1784-1796.2000. PMC 85360. PMID 10669754.
28. van der Vlag J, Otte AP (December 1999). "Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation". Nature Genetics. 23 (4): 474–478. doi:10.1038/70602. PMID 10581039. S2CID 6748531.
29. Vinatzer U, Taplick J, Seiser C, Fonatsch C, Wieser R (September 2001). "The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase". British Journal of Haematology. 114 (3): 566–573. doi:10.1046/j.1365-2141.2001.02987.x. PMID 11552981. S2CID 7643309.
30. Chakraborty S, Senyuk V, Sitailo S, Chi Y, Nucifora G (November 2001). "Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles". The Journal of Biological Chemistry. 276 (48): 44936–44943. doi:10.1074/jbc.M106733200. PMID 11568182.
31. Yang WM, Yao YL, Seto E (September 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". The EMBO Journal. 20 (17): 4814–4825. doi:10.1093/emboj/20.17.4814. PMC 125595. PMID 11532945.
32. Watamoto K, Towatari M, Ozawa Y, Miyata Y, Okamoto M, Abe A, et al. (December 2003). "Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation". Oncogene. 22 (57): 9176–9184. doi:10.1038/sj.onc.1206902. PMID 14668799. S2CID 24491249.
33. Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proceedings of the National Academy of Sciences of the United States of America. 99 (11): 7420–7425. Bibcode:2002PNAS...99.7420H. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.
34. Johnson CA, White DA, Lavender JS, O'Neill LP, Turner BM (March 2002). "Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70". The Journal of Biological Chemistry. 277 (11): 9590–9597. doi:10.1074/jbc.M107942200. PMID 11777905.
35. Cai RL, Yan-Neale Y, Cueto MA, Xu H, Cohen D (September 2000). "HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins". The Journal of Biological Chemistry. 275 (36): 27909–27916. doi:10.1074/jbc.M000168200. PMID 10846170.
36. Fischer DD, Cai R, Bhatia U, Asselbergs FA, Song C, Terry R, et al. (February 2002). "Isolation and characterization of a novel class II histone deacetylase, HDAC10". The Journal of Biological Chemistry. 277 (8): 6656–6666. doi:10.1074/jbc.M108055200. PMID 11739383.
37. Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (February 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry. 278 (9): 7234–7239. doi:10.1074/jbc.M208992200. PMID 12493763.
38. Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, et al. (January 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Molecular Cell. 9 (1): 45–57. doi:10.1016/s1097-2765(01)00429-4. hdl:11858/00-001M-0000-002C-9FF7-D. PMID 11804585.
39. Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E (September 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". The Journal of Biological Chemistry. 276 (38): 35826–35835. doi:10.1074/jbc.M104935200. PMID 11466315.
40. Ashburner BP, Westerheide SD, Baldwin AS (October 2001). "The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression". Molecular and Cellular Biology. 21 (20): 7065–7077. doi:10.1128/MCB.21.20.7065-7077.2001. PMC 99882. PMID 11564889.
41. Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (August 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes & Development. 13 (15): 1924–1935. doi:10.1101/gad.13.15.1924. PMC 316920. PMID 10444591.
42. Hassig CA, Tong JK, Fleischer TC, Owa T, Grable PG, Ayer DE, et al. (March 1998). "A role for histone deacetylase activity in HDAC1-mediated transcriptional repression". Proceedings of the National Academy of Sciences of the United States of America. 95 (7): 3519–3524. Bibcode:1998PNAS...95.3519H. doi:10.1073/pnas.95.7.3519. PMC 19868. PMID 9520398.
43. Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell. 89 (3): 357–364. doi:10.1016/s0092-8674(00)80216-0. PMID 9150135.
44. Melhuish TA, Gallo CM, Wotton D (August 2001). "TGIF2 interacts with histone deacetylase 1 and represses transcription". The Journal of Biological Chemistry. 276 (34): 32109–32114. doi:10.1074/jbc.M103377200. PMID 11427533.
45. Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (April 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development. 17 (7): 896–911. doi:10.1101/gad.252103. PMC 196026. PMID 12670868.
46. Vietor I, Vadivelu SK, Wick N, Hoffman R, Cotten M, Seiser C, et al. (September 2002). "TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells". The EMBO Journal. 21 (17): 4621–4631. doi:10.1093/emboj/cdf461. PMC 125408. PMID 12198164.
47. Koipally J, Renold A, Kim J, Georgopoulos K (June 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". The EMBO Journal. 18 (11): 3090–3100. doi:10.1093/emboj/18.11.3090. PMC 1171390. PMID 10357820.
48. Koipally J, Georgopoulos K (August 2002). "A molecular dissection of the repression circuitry of Ikaros". The Journal of Biological Chemistry. 277 (31): 27697–27705. doi:10.1074/jbc.M201694200. PMID 12015313.
49. Vieyra D, Loewith R, Scott M, Bonnefin P, Boisvert FM, Cheema P, et al. (August 2002). "Human ING1 proteins differentially regulate histone acetylation". The Journal of Biological Chemistry. 277 (33): 29832–29839. doi:10.1074/jbc.M200197200. PMID 12015309.
50. Sakai H, Urano T, Ookata K, Kim MH, Hirai Y, Saito M, et al. (December 2002). "MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase". The Journal of Biological Chemistry. 277 (50): 48714–48723. doi:10.1074/jbc.M208461200. PMID 12354758.
51. Saito M, Ishikawa F (September 2002). "The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2". The Journal of Biological Chemistry. 277 (38): 35434–35439. doi:10.1074/jbc.M203455200. PMID 12124384.
52. Ding Z, Gillespie LL, Paterno GD (January 2003). "Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain". Molecular and Cellular Biology. 23 (1): 250–258. doi:10.1128/mcb.23.1.250-258.2003. PMC 140656. PMID 12482978.
53. Xia ZB, Anderson M, Diaz MO, Zeleznik-Le NJ (July 2003). "MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein". Proceedings of the National Academy of Sciences of the United States of America. 100 (14): 8342–8347. Bibcode:2003PNAS..100.8342X. doi:10.1073/pnas.1436338100. PMC 166231. PMID 12829790.
54. Mazumdar A, Wang RA, Mishra SK, Adam L, Bagheri-Yarmand R, Mandal M, et al. (January 2001). "Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor". Nature Cell Biology. 3 (1): 30–37. doi:10.1038/35050532. PMID 11146623. S2CID 23477845.
55. You A, Tong JK, Grozinger CM, Schreiber SL (February 2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 98 (4): 1454–1458. Bibcode:2001PNAS...98.1454Y. doi:10.1073/pnas.98.4.1454. PMC 29278. PMID 11171972.
56. Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T (October 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature. 419 (6907): 641–645. Bibcode:2002Natur.419..641Y. doi:10.1038/nature01084. OSTI 805149. PMID 12374985. S2CID 25822700.
57. Ito A, Kawaguchi Y, Lai CH, Kovacs JJ, Higashimoto Y, Appella E, et al. (November 2002). "MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation". The EMBO Journal. 21 (22): 6236–6245. doi:10.1093/emboj/cdf616. PMC 137207. PMID 12426395.
58. Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, et al. (September 1999). "MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex". Nature Genetics. 23 (1): 58–61. doi:10.1038/12659. hdl:1842/684. PMID 10471499. S2CID 6147725.
59. Brackertz M, Boeke J, Zhang R, Renkawitz R (October 2002). "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3". The Journal of Biological Chemistry. 277 (43): 40958–40966. doi:10.1074/jbc.M207467200. PMID 12183469.
60. Wotton D, Lo RS, Lee S, Massagué J (April 1999). "A Smad transcriptional corepressor". Cell. 97 (1): 29–39. doi:10.1016/s0092-8674(00)80712-6. PMID 10199400. S2CID 6907878.
61. Polesskaya A, Rudnicki MA (December 2002). "A MyoD-dependent differentiation checkpoint: ensuring genome integrity". Developmental Cell. 3 (6): 757–758. doi:10.1016/s1534-5807(02)00372-6. PMID 12479798.
62. Mal A, Sturniolo M, Schiltz RL, Ghosh MK, Harter ML (April 2001). "A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program". The EMBO Journal. 20 (7): 1739–1753. doi:10.1093/emboj/20.7.1739. PMC 145490. PMID 11285237.
63. Zhong H, May MJ, Jimi E, Ghosh S (March 2002). "The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1". Molecular Cell. 9 (3): 625–636. doi:10.1016/s1097-2765(02)00477-x. PMID 11931769.
64. Underhill C, Qutob MS, Yee SP, Torchia J (December 2000). "A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1". The Journal of Biological Chemistry. 275 (51): 40463–40470. doi:10.1074/jbc.M007864200. PMID 11013263.
65. Zupkovitz G, Lagger S, Martin D, Steiner M, Hagelkruys A, Seiser C, et al. (28 June 2018). "Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri". Histochemistry and Cell Biology. 150 (3): 255–269. doi:10.1007/s00418-018-1687-4. PMC 6096771. PMID 29951776.
66. Milutinovic S, Zhuang Q, Szyf M (June 2002). "Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification". The Journal of Biological Chemistry. 277 (23): 20974–20978. doi:10.1074/jbc.M202504200. PMID 11929879.
67. Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, et al. (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochemical and Biophysical Research Communications. 322 (2): 601–608. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.
68. Joshi B, Ko D, Ordonez-Ercan D, Chellappan SP (December 2003). "A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis". Biochemical and Biophysical Research Communications. 312 (2): 459–466. doi:10.1016/j.bbrc.2003.10.148. PMID 14637159.
69. Wang S, Fusaro G, Padmanabhan J, Chellappan SP (December 2002). "Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression". Oncogene. 21 (55): 8388–8396. doi:10.1038/sj.onc.1205944. PMID 12466959. S2CID 22880111.
70. Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, et al. (June 2001). "Role of PML and PML-RARalpha in Mad-mediated transcriptional repression". Molecular Cell. 7 (6): 1233–1243. doi:10.1016/s1097-2765(01)00257-x. PMID 11430826.
71. Wu WS, Vallian S, Seto E, Yang WM, Edmondson D, Roth S, et al. (April 2001). "The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases". Molecular and Cellular Biology. 21 (7): 2259–2268. doi:10.1128/MCB.21.7.2259-2268.2001. PMC 86860. PMID 11259576.
72. Zhang Y, Dufau ML (June 2003). "Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes". The Journal of Steroid Biochemistry and Molecular Biology. 85 (2–5): 401–414. doi:10.1016/s0960-0760(03)00230-9. PMID 12943729. S2CID 28512341.
73. Zhang Y, Dufau ML (September 2002). "Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex". The Journal of Biological Chemistry. 277 (36): 33431–33438. doi:10.1074/jbc.M204417200. PMID 12091390.
74. Nicolas E, Ait-Si-Ali S, Trouche D (August 2001). "The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein". Nucleic Acids Research. 29 (15): 3131–3136. doi:10.1093/nar/29.15.3131. PMC 55834. PMID 11470869.
75. Hassig CA, Fleischer TC, Billin AN, Schreiber SL, Ayer DE (May 1997). "Histone deacetylase activity is required for full transcriptional repression by mSin3A". Cell. 89 (3): 341–347. doi:10.1016/s0092-8674(00)80214-7. PMID 9150133. S2CID 14233219.
76. Kiernan R, Brès V, Ng RW, Coudart MP, El Messaoudi S, Sardet C, et al. (January 2003). "Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65". The Journal of Biological Chemistry. 278 (4): 2758–2766. doi:10.1074/jbc.M209572200. PMID 12419806.
77. Anderson LA, Perkins ND (August 2002). "The large subunit of replication factor C interacts with the histone deacetylase, HDAC1". The Journal of Biological Chemistry. 277 (33): 29550–29554. doi:10.1074/jbc.M200513200. PMID 12045192.
78. Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D (September 1998). "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase". Proceedings of the National Academy of Sciences of the United States of America. 95 (18): 10493–10498. Bibcode:1998PNAS...9510493F. doi:10.1073/pnas.95.18.10493. PMC 27922. PMID 9724731.
79. Lai A, Lee JM, Yang WM, DeCaprio JA, Kaelin WG, Seto E, et al. (October 1999). "RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins". Molecular and Cellular Biology. 19 (10): 6632–6641. doi:10.1128/mcb.19.10.6632. PMC 84642. PMID 10490602.
80. Dick FA, Sailhamer E, Dyson NJ (May 2000). "Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins". Molecular and Cellular Biology. 20 (10): 3715–3727. doi:10.1128/mcb.20.10.3715-3727.2000. PMC 85672. PMID 10779361.
81. Fuks F, Burgers WA, Brehm A, Hughes-Davies L, Kouzarides T (January 2000). "DNA methyltransferase Dnmt1 associates with histone deacetylase activity". Nature Genetics. 24 (1): 88–91. doi:10.1038/71750. PMID 10615135. S2CID 20428600.
82. Luo RX, Postigo AA, Dean DC (February 1998). "Rb interacts with histone deacetylase to repress transcription". Cell. 92 (4): 463–473. doi:10.1016/s0092-8674(00)80940-x. PMID 9491888. S2CID 18857544.
83. Bouzahzah B, Fu M, Iavarone A, Factor VM, Thorgeirsson SS, Pestell RG (August 2000). "Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo". Cancer Research. 60 (16): 4531–4537. PMID 10969803.
84. Huang NE, Lin CH, Lin YS, Yu WC (June 2003). "Modulation of YY1 activity by SAP30". Biochemical and Biophysical Research Communications. 306 (1): 267–275. doi:10.1016/S0006-291X(03)00966-5. PMID 12788099.
85. Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, et al. (June 1998). "SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex". Molecular Cell. 1 (7): 1021–1031. doi:10.1016/s1097-2765(00)80102-1. PMID 9651585.
86. Swanson KA, Knoepfler PS, Huang K, Kang RS, Cowley SM, Laherty CD, et al. (August 2004). "HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations". Nature Structural & Molecular Biology. 11 (8): 738–746. doi:10.1038/nsmb798. PMID 15235594. S2CID 44324333.
87. Yochum GS, Ayer DE (July 2001). "Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex". Molecular and Cellular Biology. 21 (13): 4110–4118. doi:10.1128/MCB.21.13.4110-4118.2001. PMC 87072. PMID 11390640.
88. Fleischer TC, Yun UJ, Ayer DE (May 2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Molecular and Cellular Biology. 23 (10): 3456–3467. doi:10.1128/mcb.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
89. Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, Benedetti D, et al. (February 2003). "An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B". The Biochemical Journal. 369 (Pt 3): 651–657. doi:10.1042/BJ20020854. PMC 1223118. PMID 12398767.
90. Zhang J, Kalkum M, Chait BT, Roeder RG (March 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Molecular Cell. 9 (3): 611–623. doi:10.1016/s1097-2765(02)00468-9. PMID 11931768.
91. Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA (January 2000). "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway". Genes & Development. 14 (1): 45–54. doi:10.1101/gad.14.1.45. PMC 316335. PMID 10640275.
92. Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, et al. (May 2001). "Sharp, an inducible cofactor that integrates nuclear receptor repression and activation". Genes & Development. 15 (9): 1140–1151. doi:10.1101/gad.871201. PMC 312688. PMID 11331609.
93. Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, et al. (April 2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex". Molecular and Cellular Biology. 22 (8): 2743–2750. doi:10.1128/mcb.22.8.2743-2750.2002. PMC 133736. PMID 11909966.
94. Vaute O, Nicolas E, Vandel L, Trouche D (January 2002). "Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases". Nucleic Acids Research. 30 (2): 475–481. doi:10.1093/nar/30.2.475. PMC 99834. PMID 11788710.
95. Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, et al. (September 2003). "Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter". The Journal of Biological Chemistry. 278 (38): 36496–36504. doi:10.1074/jbc.M306694200. PMID 12847090.
96. Singh J, Murata K, Itahana Y, Desprez PY (March 2002). "Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex". Oncogene. 21 (12): 1812–1822. doi:10.1038/sj.onc.1205252. PMID 11896613. S2CID 30129174.
97. Sun JM, Chen HY, Moniwa M, Litchfield DW, Seto E, Davie JR (September 2002). "The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2". The Journal of Biological Chemistry. 277 (39): 35783–35786. doi:10.1074/jbc.C200378200. PMID 12176973.
98. Tsai SC, Valkov N, Yang WM, Gump J, Sullivan D, Seto E (November 2000). "Histone deacetylase interacts directly with DNA topoisomerase II". Nature Genetics. 26 (3): 349–353. doi:10.1038/81671. PMID 11062478. S2CID 19301396.
99. Johnson CA, Padget K, Austin CA, Turner BM (February 2001). "Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis". The Journal of Biological Chemistry. 276 (7): 4539–4542. doi:10.1074/jbc.C000824200. PMID 11136718.
100. Chauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard LL, Mishal Z, et al. (November 2004). "HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF". Oncogene. 23 (54): 8777–8784. doi:10.1038/sj.onc.1208128. PMID 15467736. S2CID 26092755.
101. Wong CW, Privalsky ML (October 1998). "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6". The Journal of Biological Chemistry. 273 (42): 27695–27702. doi:10.1074/jbc.273.42.27695. PMID 9765306.

Further reading

• Wolffe AP (April 1996). "Histone deacetylase: a regulator of transcription". Science. 272 (5260). New York, N.Y.: 371–372. Bibcode:1996Sci...272..371W. doi:10.1126/science.272.5260.371. PMID 8602525. S2CID 27257723.
• Ahringer J (August 2000). "NuRD and SIN3 histone deacetylase complexes in development". Trends in Genetics. 16 (8): 351–356. doi:10.1016/S0168-9525(00)02066-7. PMID 10904264.
• Verdin E, Dequiedt F, Kasler HG (May 2003). "Class II histone deacetylases: versatile regulators". Trends in Genetics. 19 (5): 286–293. doi:10.1016/S0168-9525(03)00073-8. hdl:2268/80861. PMID 12711221.
• Zhang Y, Dufau ML (June 2003). "Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes". The Journal of Steroid Biochemistry and Molecular Biology. 85 (2–5): 401–414. doi:10.1016/S0960-0760(03)00230-9. PMID 12943729. S2CID 28512341.
• Stevens M, De Clercq E, Balzarini J (September 2006). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention". Medicinal Research Reviews. 26 (5): 595–625. doi:10.1002/med.20081. PMC 7168390. PMID 16838299.
• Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (June 1995). "E2F-5, a new E2F family member that interacts with p130 in vivo". Molecular and Cellular Biology. 15 (6): 3082–3089. doi:10.1128/mcb.15.6.3082. PMC 230539. PMID 7760804.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Margolis DM, Somasundaran M, Green MR (February 1994). "Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". Journal of Virology. 68 (2): 905–910. doi:10.1128/JVI.68.2.905-910.1994. PMC 236527. PMID 8289393.
• Furukawa Y, Kawakami T, Sudo K, Inazawa J, Matsumine A, Akiyama T, et al. (1996). "Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae". Cytogenetics and Cell Genetics. 73 (1–2): 130–133. doi:10.1159/000134323. PMID 8646880.
• Hassig CA, Fleischer TC, Billin AN, Schreiber SL, Ayer DE (May 1997). "Histone deacetylase activity is required for full transcriptional repression by mSin3A". Cell. 89 (3): 341–347. doi:10.1016/S0092-8674(00)80214-7. PMID 9150133. S2CID 14233219.
• Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN (May 1997). "Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression". Cell. 89 (3): 349–356. doi:10.1016/S0092-8674(00)80215-9. PMID 9150134. S2CID 13490886.
• Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell. 89 (3): 357–364. doi:10.1016/S0092-8674(00)80216-0. PMID 9150135.
• Romerio F, Gabriel MN, Margolis DM (December 1997). "Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF". Journal of Virology. 71 (12): 9375–9382. doi:10.1128/JVI.71.12.9375-9382.1997. PMC 230241. PMID 9371597.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Brehm A, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T (February 1998). "Retinoblastoma protein recruits histone deacetylase to repress transcription". Nature. 391 (6667): 597–601. Bibcode:1998Natur.391..597B. doi:10.1038/35404. PMID 9468139. S2CID 4326464.
• Magnaghi-Jaulin L, Groisman R, Naguibneva I, Robin P, Lorain S, Le Villain JP, et al. (February 1998). "Retinoblastoma protein represses transcription by recruiting a histone deacetylase". Nature. 391 (6667): 601–605. Bibcode:1998Natur.391..601M. doi:10.1038/35410. PMID 9468140. S2CID 4315457.
• Lin RJ, Nagy L, Inoue S, Shao W, Miller WH, Evans RM (February 1998). "Role of the histone deacetylase complex in acute promyelocytic leukaemia". Nature. 391 (6669): 811–814. Bibcode:1998Natur.391..811L. doi:10.1038/35895. PMID 9486654. S2CID 4383951.
• Luo RX, Postigo AA, Dean DC (February 1998). "Rb interacts with histone deacetylase to repress transcription". Cell. 92 (4): 463–473. doi:10.1016/S0092-8674(00)80940-X. PMID 9491888. S2CID 18857544.

External links

• HDAC1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)