D-galactose 1-dehydrogenase

d-galactose 1-dehydrogenase
Identifiers
EC no.	1.1.1.48
CAS no.	9028-54-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a d-galactose 1-dehydrogenase (EC 1.1.1.48) is an enzyme that catalyzes the chemical reaction

d-galactose + NAD⁺ ${\displaystyle \rightleftharpoons }$ d-galactono-1,4-lactone + NADH + H⁺

Thus, the two substrates of this enzyme are d-galactose and NAD⁺, whereas its 3 products are d-galactono-1,4-lactone, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is d-galactose:NAD⁺ 1-oxidoreductase. Other names in common use include d-galactose dehydrogenase, beta-galactose dehydrogenase, and NAD⁺-dependent d-galactose dehydrogenase. This enzyme participates in galactose metabolism.

References

• De Ley J, Doudoroff M (1957). "The metabolism of D-galactose in Pseudomonas saccharophila". J. Biol. Chem. 227 (2): 745–57. PMID 13462997.
• Hu, ASL; Cline AL (1964). "The regulation of some sugar dehydrogenases in a pseudomonad". Biochim. Biophys. Acta. 93: 237–245. doi:10.1016/0304-4165(64)90371-x. PMID 14251301.