D-malate dehydrogenase (decarboxylating)

D-malate dehydrogenase (decarboxylating)
Identifiers
EC no.	1.1.1.83
CAS no.	37250-20-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a D-malate dehydrogenase (decarboxylating) (EC 1.1.1.83) is an enzyme that catalyzes the chemical reaction

(R)-malate + NAD⁺ ${\displaystyle \rightleftharpoons }$ pyruvate + CO₂ + NADH

Thus, the two substrates of this enzyme are (R)-malate and NAD⁺, whereas its 3 products are pyruvate, CO₂, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of a donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-malate:NAD⁺ oxidoreductase (decarboxylating). Other names in common use include D-malate dehydrogenase, D-malic enzyme, bifunctional L(+)-tartrate dehydrogenase-D(+)-malate (decarboxylating). This enzyme participates in butanoate metabolism.

References

• Stern JR, O'Brien RW (1969). "Oxidation of d-Malic and β-Alkylmalic Acids by Wild-Type and Mutant Strains of Salmonella typhimurium and by Aerobacter aerogenes". J. Bacteriol. 98 (1): 147–51. doi:10.1128/JB.98.1.147-151.1969. PMC 249916. PMID 4889267.