CDKL2

CDKL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AAA, 4BBM
Identifiers
Aliases	CDKL2, KKIAMRE, P56, cyclin dependent kinase like 2
External IDs	OMIM: 603442; MGI: 1858227; HomoloGene: 55793; GeneCards: CDKL2; OMA:CDKL2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.1 Start 75,576,496 bp[1] End 75,630,716 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E2 Start 92,006,074 bp[2] End 92,043,883 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus postcentral gyrus superior frontal gyrus testicle primary visual cortex entorhinal cortex lower lobe of lung prefrontal cortex Top expressed in barrel cortex lumbar spinal ganglion spermatocyte facial motor nucleus seminiferous tubule olfactory epithelium spermatid vestibular sensory epithelium zygote Epithelium of choroid plexus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding protein serine/threonine kinase activity ATP binding kinase activity cyclin-dependent protein serine/threonine kinase activity Cellular component cytoplasm centrosome nucleus Biological process protein phosphorylation sex differentiation phosphorylation signal transduction regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8999 53886 Ensembl ENSG00000138769 ENSMUSG00000029403 UniProt Q92772 Q9QUK0 RefSeq (mRNA) NM_003948 NM_001330724 NM_001276315 NM_016912 NM_177270 RefSeq (protein) NP_001317653 NP_003939 NP_001263244 NP_058608 NP_796244 Location (UCSC) Chr 4: 75.58 – 75.63 Mb Chr 5: 92.01 – 92.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cyclin-dependent kinase-like 2 is an enzyme that in humans is encoded by the CDKL2 gene.^[5][6]

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000138769 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029403 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Taglienti CA, Wysk M, Davis RJ (Feb 1997). "Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE". Oncogene. 13 (12): 2563–2574. PMID 9000130.
6. "Entrez Gene: CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase)".

Further reading

• Marracci GH, Marquardt WE, Strehlow A, McKeon GP, Gross J, Buck DC, et al. (Jun 2006). "Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck)". Biochemical and Biophysical Research Communications. 344 (3): 963–971. doi:10.1016/j.bbrc.2006.03.172. PMID 16631599.
• Sarkar SN, Peters KL, Elco CP, Sakamoto S, Pal S, Sen GC (Nov 2004). "Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling". Nature Structural & Molecular Biology. 11 (11): 1060–1067. doi:10.1038/nsmb847. PMID 15502848. S2CID 6869429.
• Tao J, Esch H, Hagedorn-Greiwe M, Hoffmann K, Moser B, Raynaud M, et al. (Dec 2004). "Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation". American Journal of Human Genetics. 75 (6): 1149–1154. doi:10.1086/426460. PMC 1182152. PMID 15499549.
• Sanger Center, Genome Sequencing Center (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Marcilla A, Rivero-Lezcano OM, Agarwal A, Robbins KC (Apr 1995). "Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors". Journal of Biological Chemistry. 270 (16): 9115–9120. doi:10.1074/jbc.270.16.9115. PMID 7721825.

External links

• Human CDKL2 genome location and CDKL2 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: Q92772 (Cyclin-dependent kinase-like 2) at the PDBe-KB.