MKNK2

MKNK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AC3, 2AC5
Identifiers
Aliases	MKNK2, GPRK7, MNK2, MAP kinase interacting serine/threonine kinase 2, MAPK interacting serine/threonine kinase 2
External IDs	OMIM: 605069; MGI: 894279; HomoloGene: 49674; GeneCards: MKNK2; OMA:MKNK2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 2,037,465 bp[1] End 2,051,244 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 80,501,161 bp[2] End 80,513,946 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superior surface of tongue parotid gland body of tongue mucosa of pharynx amniotic fluid gastrocnemius muscle buccal mucosa cell skin of thigh tibialis anterior muscle Skeletal muscle tissue of rectus abdominis Top expressed in subcutaneous adipose tissue brown adipose tissue temporal muscle ankle digastric muscle white adipose tissue tunica adventitia of aorta intercostal muscle sternocleidomastoid muscle triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity calcium-dependent protein serine/threonine kinase activity metal ion binding calmodulin binding kinase activity protein serine/threonine kinase activity protein binding calmodulin-dependent protein kinase activity ATP binding Cellular component cytoplasm PML body nuclear body nucleus nucleoplasm Biological process intracellular signal transduction phosphorylation protein phosphorylation cell surface receptor signaling pathway cellular response to arsenic-containing substance peptidyl-serine phosphorylation extrinsic apoptotic signaling pathway in absence of ligand protein autophosphorylation regulation of translation apoptotic process hemopoiesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2872 17347 Ensembl ENSG00000099875 ENSMUSG00000020190 UniProt Q9HBH9 Q8CDB0 RefSeq (mRNA) NM_199054 NM_017572 NM_021462 RefSeq (protein) NP_060042 NP_951009 NP_067437 Location (UCSC) Chr 19: 2.04 – 2.05 Mb Chr 10: 80.5 – 80.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.^[5][6]

Interactions

MNK2 has been shown to interact with MAPK1^[7][8] and Eukaryotic translation initiation factor 4 gamma.^[7]

MNK2 has been identified as a therapeutic target for diabetes. Specifically, blocking MNK2 interaction with eIF4G has been shown to boost protein synthesis and promote beta cell regeneration.^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000099875 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020190 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Slentz-Kesler K, Moore JT, Lombard M, Zhang J, Hollingsworth R, Weiner MP (October 2000). "Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta". Genomics. 69 (1): 63–71. doi:10.1006/geno.2000.6299. PMID 11013076.
6. "Entrez Gene: MKNK2 MAP kinase interacting serine/threonine kinase 2".
7. Scheper GC, Parra JL, Wilson M, Van Kollenburg B, Vertegaal AC, Han ZG, Proud CG (August 2003). "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization". Molecular and Cellular Biology. 23 (16): 5692–5705. doi:10.1128/MCB.23.16.5692-5705.2003. PMC 166352. PMID 12897141.
8. Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (April 1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". The EMBO Journal. 16 (8): 1909–1920. doi:10.1093/emboj/16.8.1909. PMC 1169794. PMID 9155017.
9. Karampelias C, Watt K, Mattsson CL, Ruiz ÁF, Rezanejad H, Mi J, et al. (September 2022). "MNK2 deficiency potentiates β-cell regeneration via translational regulation". Nature Chemical Biology. 18 (9): 942–953. doi:10.1038/s41589-022-01047-x. PMC 7613404. PMID 35697798.

Further reading

• Haribabu B, Snyderman R (October 1993). "Identification of additional members of human G-protein-coupled receptor kinase multigene family". Proceedings of the National Academy of Sciences of the United States of America. 90 (20): 9398–9402. Bibcode:1993PNAS...90.9398H. doi:10.1073/pnas.90.20.9398. PMC 47575. PMID 8415712.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (April 1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". The EMBO Journal. 16 (8): 1909–1920. doi:10.1093/emboj/16.8.1909. PMC 1169794. PMID 9155017.
• Scheper GC, Morrice NA, Kleijn M, Proud CG (February 2001). "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells". Molecular and Cellular Biology. 21 (3): 743–754. doi:10.1128/MCB.21.3.743-754.2001. PMC 86666. PMID 11154262.
• Knauf U, Tschopp C, Gram H (August 2001). "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2". Molecular and Cellular Biology. 21 (16): 5500–5511. doi:10.1128/MCB.21.16.5500-5511.2001. PMC 87272. PMID 11463832.
• Scheper GC, Parra JL, Wilson M, Van Kollenburg B, Vertegaal AC, Han ZG, Proud CG (August 2003). "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization". Molecular and Cellular Biology. 23 (16): 5692–5705. doi:10.1128/MCB.23.16.5692-5705.2003. PMC 166352. PMID 12897141.
• Yoshizuka N, Yoshizuka-Chadani Y, Krishnan V, Zeichner SL (September 2005). "Human immunodeficiency virus type 1 Vpr-dependent cell cycle arrest through a mitogen-activated protein kinase signal transduction pathway". Journal of Virology. 79 (17): 11366–11381. doi:10.1128/JVI.79.17.11366-11381.2005. PMC 1193619. PMID 16103188.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Jauch R, Jäkel S, Netter C, Schreiter K, Aicher B, Jäckle H, Wahl MC (October 2005). "Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site". Structure. 13 (10): 1559–1568. doi:10.1016/j.str.2005.07.013. hdl:11858/00-001M-0000-0010-9408-D. PMID 16216586.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Wang P, Wang X, Wang F, Cai T, Luo Y (June 2006). "Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex". Science in China Series C: Life Sciences. 49 (3): 265–273. doi:10.1007/s11427-006-0265-5. PMID 16856496. S2CID 23339861.