The 2006 NCAA Division I men's soccer tournament was a tournament of 48 teams from NCAA Division I who played for the NCAA Championship in soccer. The College Cup Final Four was held at Hermann Stadium in St. Louis, Missouri. All the other games were played at the home field of the higher-seeded team. The final was held on December 3, 2006. UC Santa Barbara, UCLA, Virginia, and Wake Forest made the Final Four. UC Santa Barbara beat Wake Forest and UCLA defeated Virginia. In the final UC Santa Barbara won the title game overcoming UCLA, 2–1.
The tournament started on November 10, 2006. The first round was played on November 10 and 11. The second round on the 15th, and the third round on the 18th and 19th. The Regional Finals were played on November 24–26.