The senior side represents the best South African born and developed players as selected from clubs and leagues of AFL South Africa.
South Africa had its international debut at the 2002 Australian Football International Cup but the inexperienced team went through the tournament winless. It registered its first international win in the 2005 Australian Football International Cup against Japan. Between 2007 and 2010, through significant development funding and reciprocal tours, South Africa competed annually against the AFL Academy (Australia's Under 17 team) and against numerous touring amateur teams from Australia. This resulted in a dramatic improvement at senior level, with South Africa achieving its best result, 3rd overall in the 2008 AFIC.
They have worn a different jumper at each International Cup, with the first jumper green with gold and red wings, the second green with a gold yoke, and the current jumper based on the Flag of South Africa with a stylised Lion.
A much improved Buffaloes outfit (reflecting the development of junior footy in South Africa) achieved 8th ranking at the 2005 International Cup.
The Buffalo's best and fairest player (from the 2005 International Cup) is Steven Malinga.
Since 2006, the team has played annually against the "Flying Boomerangs" under 18 indigenous Australian squad, with tours alternating between South Africa and the Northern Territory in Australia.
Later in that year, the Buffaloes defeated the touring Australian Convicts side.
In the warm-up to the 2008 Australian Football International Cup, South Africa gave a Melbourne-based multicultural team organised by the AFL and known as "Team Africa" a football lesson. Surprising many with their skill and pace, they went on to go undefeated through the first 3 pool rounds including a win against the USA and secured a finals berth against the 2005 runners-up Papua New Guinea. However Papua New Guinea were too good for the much improved South Africans.