Mohamed Al-Zeno's career began with the Al-Ittihad Aleppo youth squad under coach Omar Al-Shaaban in the "Al-Smoud Football School" in Aleppo. Later he joined the youth team of Shorta Aleppo. After playing a few games in the Al-Shorta under-17 youth team, he moved Al-Shorta's first team and in 1999 he signed his first professional contract.[citation needed]
He moved to Al-Jaish SC of Damascus in 2004. He played for Al-Jaish for three seasons. In his first season with Al-Jaish, he won the 2004 AFC Cup, the second biggest association cup in Asia. In the second-leg of the quarter-finals, he scored one goal in 3–0 win over Indian champions Kingfisher East Bengal FC In the semi-finals, he scored one goal each in both the legs, one in the first-leg in a 4–0 win and another in the second-leg in a 2–1 win over Singaporean champions Home United FC and hence helped his team to reach the AFC Cup finals for the first time.[citation needed]
He was a part of the Syria national football team in the 2007 Nehru Cup in India. He scored two goals in the friendly tournament, one in a 4–1 win over Kyrgyzstan and another in a 5–1 win over Cambodia.[citation needed]
In the 2009 Nehru Cup, he scored three goals, one goal in a 2–0 victory over Kyrgyzstan in Syria's first match of the tournament.[7] He also scored a goal in Syria's 4–0 win over Sri Lanka and another in a 1–0 win over Lebanon. At the end of the tournament, he was awarded with the "Top Goal Scorer" award.[citation needed]