戴维·博特斯坦

戴维·博特斯坦
David Botstein
出生 (1942-09-08) 1942年9月8日（82歲）
 瑞士蘇黎世
母校哈佛大學
密西根大學
奖项礼来公司微生物学奖（1978年）
Genetics Society of America Medal（1988年）[3]
Allan Award of the American Society of Human Genetics（1989年）
格鲁伯遗传学奖（2003年）
Albany Medical Center Prize（2010年）
生命科学突破奖（2013年）
托马斯·亨特·摩尔根奖章（2020年）
网站www.princeton.edu/genomics/botstein
molbio.princeton.edu/faculty/molbio-faculty/96-botstein
科学生涯
研究领域生物學
机构麻省理工學院
史丹佛大學
基因泰克
普林斯頓大學
论文The Synthesis and Maturation of Phage-P22 DNA（1967年）
博士生Olga Troyanskaya[1]
Nikolai Slavov[2]
其他著名學生Michael Eisen（博士後）

戴维·博特斯坦（英語：David Botstein，1942年9月8日—），美國生物學家，出生於瑞士蘇黎世，自2003年以來，博特斯坦於普林斯頓大學負責綜合基因組學的劉易斯－西格勒研究所，出任研究所主任[4][5][6][7]。

生平

1980年，博特斯坦和他的同事，雷·怀特（Ray White）、马克·什科尔尼克（Mark Skolnick）、以及罗纳德·W·戴维斯提出一個以限制性片段長度多態性來建構遺傳連鎖圖譜的方法[8]，隨後的幾年間，使用此方法來鑑別出幾個人類疾病的基因片斷，其中包括亨丁頓舞蹈症和第一型乳腺癌易感蛋白（BRCA1）。人类基因組計畫的定序階段便是使用這種方法的幾種變化式。

在1998年，博特斯坦和他的博士后研究员迈克尔·艾森（Michael Eisen）、研究生保罗·斯佩尔曼、以及同事帕特里克·布朗，合力研發出一套統計方法與圖形界面，被廣泛應用於解釋基因組數據，包括生物晶片[9]。

參考文獻

  1. ^ Justin Mullins, BJ Morrison McKay. International Society for Computational Biology Honors Michael Ashburner and Olga Troyanskaya with Top Bioinformatics/Computational Biology Awards for 2011. PLOS Computational Biology. 2011-06-02, 7 (6): e1002081 [2018-04-02]. ISSN 1553-7358. doi:10.1371/journal.pcbi.1002081. （原始内容存档于2020-10-01） （英语）. 
  2. ^ 存档副本. [2013-10-10]. （原始内容存档于2012-12-12）. 
  3. ^ A. P. Mahowald. Genetics society of america records, proceedings and reports. Genetics. 1988-06, 119 (2): s1–s15 [2019-05-25]. ISSN 0016-6731. PMC 1203430 可免费查阅. PMID 17246435. （原始内容存档于2019-08-20）. 
  4. ^ 存档副本. [2006-11-08]. （原始内容存档于2006-11-27）.  David Botstein at Princeton Department of Molecular Biology
  5. ^ http://www.princeton.edu/genomics/botstein/ （页面存档备份，存于互联网档案馆） Botstein Laboratory Princeton
  6. ^ Jane Gitschier. Willing to Do the Math: An Interview with David Botstein. PLOS Genetics. 2006-05-26, 2 (5): e79 [2018-04-02]. ISSN 1553-7404. doi:10.1371/journal.pgen.0020079. （原始内容存档于2021-01-28） （英语）. 
  7. ^ 存档副本. [2012-07-24]. （原始内容存档于2012-07-24）.  The Daily Princetonian - Mapping the path of genetics
  8. ^ D. Botstein, R. L. White, M. Skolnick, R. W. Davis. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. American Journal of Human Genetics. 1980-05, 32 (3): 314–331 [2019-05-25]. ISSN 0002-9297. PMC 1686077 可免费查阅. PMID 6247908. （原始内容存档于2020-05-06）. 
  9. ^ M. B. Eisen, P. T. Spellman, P. O. Brown, D. Botstein. Cluster analysis and display of genome-wide expression patterns. Proceedings of the National Academy of Sciences of the United States of America. 1998-12-08, 95 (25): 14863–14868 [2019-02-13]. ISSN 0027-8424. PMC 24541 可免费查阅. PMID 9843981. （原始内容存档于2019-08-24）. 

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