Tropomiozinska receptorska kinaza B

NTRK2
Available structures
PDB	Pretraga ortologa: PDBe RCSB
List of PDB id codes
	4AT5, 1HCF, 1WWB, 2MFQ, 4ASZ, 4AT3, 4AT4
Identifikatori
Alijasi	NTRK2
Spoljašnji ID	OMIM: 600456 MGI: 97384 HomoloGene: 4504 GeneCards: NTRK2
Genska lokacija (miš)
Hr.	Chromosome 13 (mouse)
Kraj	59,281,784 bp
Obrazac RNK izražavanja
	; ; ; ;
	More reference expression data
Genska ontologija
Molecular function	• neurotrophin binding; • neurotrophin receptor activity; • kinase activity; • transmembrane receptor protein tyrosine kinase activity; • ATP binding; • protein kinase activity; • brain-derived neurotrophic factor binding; • transferase activity; • protein homodimerization activity; • protein tyrosine kinase activity; • nucleotide binding; • brain-derived neurotrophic factor-activated receptor activity; • GO:0001948, GO:0016582 везивање за протеине плазме; • Receptor tirozinska kinaza; • transmembrane signaling receptor activity;
Cellular component	• цитосол; • Endozom; • postsynaptic membrane; • мембрана; • terminal bouton; • саставни део мембране; • receptor complex; • endosome membrane; • integral component of plasma membrane; • GO:0097483, GO:0097481 постсинаптичка густина; • early endosome; • early endosome membrane; • ћелијска мембрана; • аксон; • дендрит; • окоједарна област цитоплазме; • цитоплазма; • cell projection; • dendritic spine; • axon terminus; • Golgi membrane;
Biological process	• GO:1904089 негативно уређење неурона процеса апоптозе; • peripheral nervous system neuron development; • positive regulation of protein phosphorylation; • oligodendrocyte differentiation; • учење; • positive regulation of axonogenesis; • Васкулогенеза; • protein phosphorylation; • central nervous system neuron development; • neuromuscular junction development; • retinal rod cell development; • биолошки часовник; • feeding behavior; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • positive regulation of peptidyl-serine phosphorylation; • brain-derived neurotrophic factor receptor signaling pathway; • regulation of protein kinase B signaling; • уређење метаболичких процеса; • positive regulation of MAPK cascade; • диференцијација; • Fosforilacija; • neuron migration; • mechanoreceptor differentiation; • ментални развој; • glutamate secretion; • retina development in camera-type eye; • neuron differentiation; • cerebral cortex development; • negative regulation of anoikis; • multicellular organism development; • GO:1901313 positive regulation of gene expression; • positive regulation of cell population proliferation; • positive regulation of neuron projection development; • cellular response to amino acid stimulus; • positive regulation of phosphatidylinositol 3-kinase signaling; • peptidyl-tyrosine phosphorylation; • long-term potentiation; • positive regulation of synapse assembly; • transmembrane receptor protein tyrosine kinase signaling pathway; • protein autophosphorylation; • trans-synaptic signaling by neuropeptide, modulating synaptic transmission; • activation of phospholipase C activity; • neurotrophin TRK receptor signaling pathway; • positive regulation of non-membrane spanning protein tyrosine kinase activity; • trans-synaptic signaling by BDNF, modulating synaptic transmission; • negative regulation of signal transduction; • neuronal action potential propagation; • myelination in peripheral nervous system; • негативно регулисање апоптотичког процеса; • positive regulation of ERK1 and ERK2 cascade; • cellular response to nerve growth factor stimulus; • regulation of MAPK cascade; • cellular response to brain-derived neurotrophic factor stimulus;
	Sources:Amigo / QuickGO
Ortolozi
	4915
	18212
	ENSG00000148053
	ENSMUSG00000055254
	Q16620
	P15209
NM_001007097; NM_001018064; NM_001018065; NM_001018066; NM_001291937;
	NM_006180
	NM_001025074; NM_008745; NM_001282961
NP_001007098; NP_001018074; NP_001018075; NP_001018076; NP_001278866;
	NP_006171; NP_001356461; NP_001356462; NP_001356463; NP_001356464; NP_001356465; NP_001356466; NP_001356467; NP_001356468; NP_001356469; NP_001356470; NP_001356471; NP_001356472; NP_001356473; NP_001356474; NP_001356475; NP_001356476; NP_001356477; NP_001356478; NP_001356479; NP_001356480; NP_001356481
	NP_001020245; NP_001269890; NP_032771
	Wikidata
View/Edit Human	View/Edit Mouse

TrkB receptor (TrkB tirozinska kinaza, receptor BDNF/NT-3 faktora rasta, receptorska neurotrofna tirozinska kinaza, tip 2) protein je koji je kod ljudi kodiran NTRK2 genom.^[4]^[5]

Interakcije

TrkB formira interakcije sa:

Neurotrofni moždani faktor (BDNF),^[6]^[7]
FYN,^[8]
NCK2,^[9]
PLCG1,^[9]^[10]
Sekvestosom 1,^[11] i
SHC3.^[9]^[12]

Ligandi

Agonisti

Moždani neurotrofni faktor (BDNF)
Neurotrofin-3 (NT-3)
Neurotrofin-4 (NT-4)
N-Acetilserotonin
HIOC
Amitriptilin^[13]
7,8-Dihidroksiflavon
7,8,3'-Trihidroksiflavon
4'-Dimetilamino-7,8-dihidroksiflavon^[14]
Deoksigedunin^[15]
LM-22A4

Vidi još

Trk receptor

Reference

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000055254 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Malenka RC, Nestler EJ, Hyman SE (2009). „Chapter 8: Atypical neurotransmitters”. Ур.: Sydor A, Brown RY. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd изд.). New York: McGraw-Hill Medical. стр. —. ISBN 9780071481274.
^ Nakagawara A, Liu XG, Ikegaki N, White PS, Yamashiro DJ, Nycum LM, Biegel JA, Brodeur GM (1995). „Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2)”. Genomics. 25 (2): 538—46. PMID 7789988. doi:10.1016/0888-7543(95)80055-Q.
^ Haniu M, Montestruque S, Bures EJ, Talvenheimo J, Toso R, Lewis-Sandy S, Welcher AA, Rohde MF (1997). „Interactions between brain-derived neurotrophic factor and the TRKB receptor. Identification of two ligand binding domains in soluble TRKB by affinity separation and chemical cross-linking”. J. Biol. Chem. 272 (40): 25296—303. PMID 9312147. doi:10.1074/jbc.272.40.25296.
^ Naylor RL, Robertson AG, Allen SJ, Sessions RB, Clarke AR, Mason GG, Burston JJ, Tyler SJ, Wilcock GK, Dawbarn D (2002). „A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4”. Biochem. Biophys. Res. Commun. 291 (3): 501—7. PMID 11855816. doi:10.1006/bbrc.2002.6468.
^ Iwasaki Y, Gay B, Wada K, Koizumi S (1998). „Association of the Src family tyrosine kinase Fyn with TrkB”. J. Neurochem. 71 (1): 106—11. PMID 9648856. doi:10.1046/j.1471-4159.1998.71010106.x.
^ ^а ^б ^в Suzuki S, Mizutani M, Suzuki K, Yamada M, Kojima M, Hatanaka H, Koizumi S (2002). „Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor”. Biochem. Biophys. Res. Commun. 294 (5): 1087—92. PMID 12074588. doi:10.1016/S0006-291X(02)00606-X.
^ Meakin SO, MacDonald JI, Gryz EA, Kubu CJ, Verdi JM (1999). „The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation”. J. Biol. Chem. 274 (14): 9861—70. PMID 10092678. doi:10.1074/jbc.274.14.9861.
^ Geetha T, Wooten MW (2003). „Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling”. J. Biol. Chem. 278 (7): 4730—9. PMID 12471037. doi:10.1074/jbc.M208468200.
^ Nakamura T, Muraoka S, Sanokawa R, Mori N (1998). „N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling”. J. Biol. Chem. 273 (12): 6960—7. PMID 9507002. doi:10.1074/jbc.273.12.6960.
^ Jang SW, Liu X, Chan CB, Weinshenker D, Hall RA, Xiao G, Ye K (2009). „Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity”. Chem. Biol. 16 (6): 644—56. PMC 2844702 . PMID 19549602. doi:10.1016/j.chembiol.2009.05.010.
^ Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, Phun LH, France S, Xiao G, Jia Y, Luo HR, Ye K (2010). „A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect”. J Med Chem. 53: 8274. PMID 21073191. doi:10.1021/jm101206p.
^ {{Cite http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011528 }}

Literatura

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Haniu M, Montestruque S, Bures EJ, Talvenheimo J, Toso R, Lewis-Sandy S, Welcher AA, Rohde MF (1997). „Interactions between brain-derived neurotrophic factor and the TRKB receptor. Identification of two ligand binding domains in soluble TRKB by affinity separation and chemical cross-linking”. J. Biol. Chem. 272 (40): 25296—303. PMID 9312147. doi:10.1074/jbc.272.40.25296.
Nakamura T, Muraoka S, Sanokawa R, Mori N (1998). „N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling”. J. Biol. Chem. 273 (12): 6960—7. PMID 9507002. doi:10.1074/jbc.273.12.6960.
Hackett SF, Friedman Z, Freund J, Schoenfeld C, Curtis R, DiStefano PS, Campochiaro PA (1998). „A splice variant of trkB and brain-derived neurotrophic factor are co-expressed in retinal pigmented epithelial cells and promote differentiated characteristics”. Brain Res. 789 (2): 201—12. PMID 9573364. doi:10.1016/S0006-8993(97)01440-6.
Iwasaki Y, Gay B, Wada K, Koizumi S (1998). „Association of the Src family tyrosine kinase Fyn with TrkB”. J. Neurochem. 71 (1): 106—11. PMID 9648856. doi:10.1046/j.1471-4159.1998.71010106.x.
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