ERBB3

ERBB3
Available structures PDB Pretraga ortologa: PDBe RCSB List of PDB id codes 1M6B, 2L9U, 3KEX, 3LMG, 3P11, 4LEO, 4OTW, 4P59, 4RIW, 4RIX, 4RIY, 5CUS
Identifikatori
Alijasi	ERBB3
Spoljašnji ID	OMIM: 190151 MGI: 95411 HomoloGene: 20457 GeneCards: ERBB3
Genska lokacija (miš) Hr. Chromosome 10 (mouse)[1] Band 10 D3|10 77.1 cM Start 128,403,392 bp[1] Kraj 128,425,521 bp[1]
Obrazac RNK izražavanja More reference expression data
Genska ontologija Molecular function • transferase activity • nucleotide binding • protein kinase activity • protein tyrosine kinase activator activity • growth factor binding • protein homodimerization activity • kinase activity • GO:0001948, GO:0016582 везивање за протеине плазме • identical protein binding • protein heterodimerization activity • ATP binding • transmembrane signaling receptor activity • neuregulin binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • protein tyrosine kinase activity • ubiquitin protein ligase binding • Receptor tirozinska kinaza • neuregulin receptor activity • transmembrane receptor protein tyrosine kinase activity Cellular component • саставни део мембране • lateral plasma membrane • мембрана • ћелијска мембрана • integral component of plasma membrane • ванћелијска област • basolateral plasma membrane • apical plasma membrane • Intracelularni • receptor complex • ванћелијски простор • цитоплазма • basal plasma membrane Biological process • neuron apoptotic process • negative regulation of cell adhesion • Fosforilacija • endocardial cushion development • positive regulation of protein tyrosine kinase activity • wound healing • MAPK cascade • positive regulation of calcineurin-NFAT signaling cascade • heart development • protein phosphorylation • negative regulation of secretion • regulation of cell population proliferation • extrinsic apoptotic signaling pathway in absence of ligand • phosphatidylinositol 3-kinase signaling • positive regulation of phosphatidylinositol 3-kinase signaling • negative regulation of signal transduction • GO:0072468 Prenos signala • cranial nerve development • GO:1904089 негативно уређење неурона процеса апоптозе • Schwann cell differentiation • phosphatidylinositol phosphate biosynthetic process • regulation of cell motility • peripheral nervous system development • transmembrane receptor protein tyrosine kinase signaling pathway • ERBB2 signaling pathway • peptidyl-tyrosine phosphorylation • positive regulation of cardiac muscle tissue development • GO:1901313 positive regulation of gene expression • positive regulation of protein kinase B signaling • диференцијација • негативно регулисање апоптотичког процеса • positive regulation of ERK1 and ERK2 cascade • ментални развој • positive regulation of cell population proliferation Sources:Amigo / QuickGO
Ortolozi
Vrste	Čovek	Miš
Entrez	2065	13867
Ensembl	ENSG00000065361	ENSMUSG00000018166
UniProt	P21860	Q61526
RefSeq (mRNA)	NM_001982 NM_001005915	NM_010153
RefSeq (protein)	NP_001005915 NP_001973	NP_034283
Location (UCSC)	n/a	Chr 10: 128.4 – 128.43 Mb
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Receptorska tirozinska proteinska kinaza erbB-3 (HER3, receptor 3 ljudskog epidermalnog faktora rasta) membranski je protein koji je kod ljudi kodiran ERBB3 genom. ErbB3 je član familjie receptora epidermalnog faktora rasta (EGFR/ERBB) koji su receptorske tirozinske kinaze.

Gen i izražavanje

Ljudski ERBB3 gen je lociran na dugačkoj ruci hromozoma 12 (12q13). On je kodiran sa 23,651 parova baza i translira se u 1342 aminokiselina.^[4]

Tokom razvića čoveka, ERBB3 je izražen u koži, kostima, mišićima, nervnom sistemu, srcu, plućima, i intestinalnom epitelu.^[5] ERBB3 je izražed kod normalnih odraslih ljudi u gastrointestinalnom traktu, reproduktivnom sistemu, koži, nervnom sistemu, urinarnom trakti, i endokrinom sistemu.^[6]

Vidi još

• Receptoraska familjia epidermalnih faktora rasta
• Receptor epidermalnog faktora rasta
• Receptorska tirozinska kinaza

Reference

1. GRCm38: Ensembl release 89: ENSMUSG00000018166 - Ensembl, May 2017
2. „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
3. „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
4. „ERBB3 Gene - GeneCards | ERBB3 Protein”. 
5. Coussens L, Yang-Feng TL, Liao YC, Chen E, Gray A, McGrath J, Seeburg PH, Libermann TA, Schlessinger J, Francke U (1985). „Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene”. Science. 230 (4730): 1132—9. PMID 2999974. doi:10.1126/science.2999974. 
6. Prigent SA, Lemoine NR, Hughes CM, Plowman GD, Selden C, Gullick WJ (1992). „Expression of the c-erbB-3 protein in normal human adult and fetal tissues”. Oncogene. 7 (7): 1273—8. PMID 1377811. 

Literatura

• Corfas G, Roy K, Buxbaum JD (2004). „Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia”. Nat. Neurosci. 7 (6): 575—80. PMID 15162166. doi:10.1038/nn1258. 
• Plowman GD, Whitney GS, Neubauer MG, et al. (1990). „Molecular cloning and expression of an additional epidermal growth factor receptor-related gene”. Proc. Natl. Acad. Sci. U.S.A. 87 (13): 4905—9. PMC 54229 . PMID 2164210. doi:10.1073/pnas.87.13.4905. 
• Kraus MH, Issing W, Miki T, et al. (1990). „Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors”. Proc. Natl. Acad. Sci. U.S.A. 86 (23): 9193—7. PMC 298460 . PMID 2687875. doi:10.1073/pnas.86.23.9193. 
• Alimandi M, Romano A, Curia MC, et al. (1995). „Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas”. Oncogene. 10 (9): 1813—21. PMID 7538656. 
• Wallasch C, Weiss FU, Niederfellner G, et al. (1995). „Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3”. EMBO J. 14 (17): 4267—75. PMC 394510 . PMID 7556068. 
• Horan T, Wen J, Arakawa T, et al. (1995). „Binding of Neu differentiation factor with the extracellular domain of Her2 and Her3”. J. Biol. Chem. 270 (41): 24604—8. PMID 7592681. doi:10.1074/jbc.270.41.24604. 
• Shintani S, Funayama T, Yoshihama Y, et al. (1995). „Prognostic significance of ERBB3 overexpression in oral squamous cell carcinoma”. Cancer Lett. 95 (1–2): 79—83. PMID 7656248. doi:10.1016/0304-3835(95)03866-U. 
• Katoh M, Yazaki Y, Sugimura T, Terada M (1993). „c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase”. Biochem. Biophys. Res. Commun. 192 (3): 1189—97. PMID 7685162. doi:10.1006/bbrc.1993.1542. 
• Culouscou JM, Plowman GD, Carlton GW, et al. (1993). „Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor”. J. Biol. Chem. 268 (25): 18407—10. PMID 7689552. 
• Zelada-Hedman M, Werer G, Collins P, et al. (1995). „High expression of the EGFR in fibroadenomas compared to breast carcinomas”. Anticancer Res. 14 (5A): 1679—88. PMID 7847801. 
• Carraway KL, Sliwkowski MX, Akita R, et al. (1994). „The erbB3 gene product is a receptor for heregulin”. J. Biol. Chem. 269 (19): 14303—6. PMID 8188716. 
• Shintani S, Funayama T, Yoshihama Y, et al. (1996). „Expression of c-erbB family gene products in adenoid cystic carcinoma of salivary glands: an immunohistochemical study”. Anticancer Res. 15 (6B): 2623—6. PMID 8669836. 
• Chang H, Riese DJ, Gilbert W, et al. (1997). „Ligands for ErbB-family receptors encoded by a neuregulin-like gene”. Nature. 387 (6632): 509—12. PMID 9168114. doi:10.1038/387509a0. 
• Carraway KL, Weber JL, Unger MJ, et al. (1997). „Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases”. Nature. 387 (6632): 512—6. PMID 9168115. doi:10.1038/387512a0. 
• Fiddes RJ, Campbell DH, Janes PW, et al. (1998). „Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3”. J. Biol. Chem. 273 (13): 7717—24. PMID 9516479. doi:10.1074/jbc.273.13.7717. 
• Jones JT, Ballinger MD, Pisacane PI, et al. (1998). „Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis”. J. Biol. Chem. 273 (19): 11667—74. PMID 9565587. doi:10.1074/jbc.273.19.11667. 
• Lee H, Maihle NJ (1998). „Isolation and characterization of four alternate c-erbB3 transcripts expressed in ovarian carcinoma-derived cell lines and normal human tissues”. Oncogene. 16 (25): 3243—52. PMID 9681822. doi:10.1038/sj.onc.1201866. 
• Vijapurkar U, Cheng K, Koland JG (1998). „Mutation of a Shc binding site tyrosine residue in ErbB3/HER3 blocks heregulin-dependent activation of mitogen-activated protein kinase”. J. Biol. Chem. 273 (33): 20996—1002. PMID 9694850. doi:10.1074/jbc.273.33.20996. 
• Yoo JY, Hamburger AW (1999). „Interaction of the p23/p198 protein with ErbB-3”. Gene. 229 (1–2): 215—21. PMID 10095121. doi:10.1016/S0378-1119(98)00604-0. 
• Lin J, Adam RM, Santiestevan E, Freeman MR (1999). „The phosphatidylinositol 3'-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells”. Cancer Res. 59 (12): 2891—7. PMID 10383151.