Glikolipid 3-a-manoziltransferaza

Glikolipid 3-a-manoziltransferaza
Identifikatori
EC broj	2.4.1.132
CAS broj	81181-76-2
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC članci PubMed članci NCBI proteini

Glikolipid 3-a-manoziltransferaza (EC 2.4.1.132, Alg2 manoziltransferaza, ALG2 (gen), glikolipid 3-alfa-manoziltransferaza, GDP-manoza:glikolipid 3-alfa-D-manoziltransferaza, GDP-Man:Man1GlcNAc2-PP-Dol alfa-1,3-manoziltransferaza) je enzim sa sistematskim imenom GDP-D-manoza:D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol 3-alfa-manoziltransferaza.^[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

GDP-D-manoza + D-MaN-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol ${\displaystyle \rightleftharpoons }$ GDP + D-MaN-alfa-(1->3)-D-MaN-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol

Pri biosintezi za asparagin vezanih glikoproteina (N-vezanoj proteinskoj glikozilaciji) se koristi za dolihil difosfat vezani glikozilni donor. Njega formira serija za membranu vezanih glikoziltransferaza.

Reference

1. Kampf, M., Absmanner, B., Schwarz, M. and Lehle, L. (2009). „Biochemical characterization and membrane topology of Alg2 from Saccharomyces cerevisiae as a bifunctional α1,3- and 1,6-mannosyltransferase involved in lipid-linked oligosaccharide biosynthesis”. J. Biol. Chem. 284: 11900—11912. PMID 19282279. CS1 одржавање: Вишеструка имена: списак аутора (веза)
2. O'Reilly, M.K., Zhang, G. and Imperiali, B. (2006). „In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis”. Biochemistry. 45: 9593—9603. PMID 16878994. CS1 одржавање: Вишеструка имена: списак аутора (веза)

Literatura

• Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
• Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 
• William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605. 

Spoljašnje veze

• GDP-Man:Man1GlcNAc2-PP-dolichol+alpha-1,3-mannosyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)