PROFILBARU.COM

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Laktoza sintaza
Laktoza sintaza
Identifikatori
EC broj	2.4.1.22
CAS broj	2604493
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Laktoza sintaza (EC 2.4.1.22, UDP-galaktoza glukoza galaktoziltransferaza, N-acetillaktozaminska sintaza, uridin difosfogalaktoza-glukoza galaktoziltransferaza, laktozna sintetaza, UDP-galaktoza:D-glukoza 4-beta-D-galaktotransferaza, UDP-galaktoza:D-glukoza 4-beta-D-galaktoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-galaktoza:D-glukoza 4-beta-D-galaktoziltransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-alfa-D-galaktoza + D-glukoza

\rightleftharpoons

UDP + laktoza

Ovaj enzim je kompleks dva proteina, A i B. U odsustvu B proteina (alfa-laktalbumina), ovaj enzim katalizuje transfer galaktoze sa UDP-alfa-D-galaktoze na N-acetilglukozamin (EC 2.4.1.90, N-acetilaktozamin sintaza).

Reference

^ Fitzgerald, D.K., Brodbeck, U., Kiyosawa, I., Mawal, R., Colvin, B. and Ebner, K.E. (1970). „α-Lactalbumin and the lactose synthetase reaction”. J. Biol. Chem. 245: 2103—2108. PMID 5440844.
^ Hill, R.L. & Brew, K. (1975). „Lactose synthetase”. Adv. Enzymol. Relat. Areas Mol. Biol. 43: 411—490. PMID 812340.
^ Watkins, W.M. & Hassid, W.Z. (1962). „The synthesis of lactose by particulate enzyme preparations from guinea pig and bovine mammary glands”. J. Biol. Chem. 237: 1432—1440. PMID 14005251.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Lactose+synthase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Fitzgerald, D.K., Brodbeck, U., Kiyosawa, I., Mawal, R., Colvin, B. and Ebner, K.E. (1970). „α-Lactalbumin and the lactose synthetase reaction”. J. Biol. Chem. 245: 2103—2108. PMID 5440844.

[2] Hill, R.L. & Brew, K. (1975). „Lactose synthetase”. Adv. Enzymol. Relat. Areas Mol. Biol. 43: 411—490. PMID 812340.

[3] Watkins, W.M. & Hassid, W.Z. (1962). „The synthesis of lactose by particulate enzyme preparations from guinea pig and bovine mammary glands”. J. Biol. Chem. 237: 1432—1440. PMID 14005251.

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