Carboplatin

Carboplatin is a drug used in chemotherapy. It is one of a group of related drugs called platins, which have a central platinum atom surrounded by four or six l

Carboplatin

Carboplatin is a drug used in chemotherapy. It is one of a group of related drugs called platins, which have a central platinum atom surrounded by four or six ligands. Carboplatin was invented to be a less toxic alternative to cisplatin.[1]

Structure

Like all platins, carboplatin is a platinum coordination complex. Instead of the two chloride ions that are ligands in cisplatin, carboplatin has one 1,1-cyclobutane dicarboxylate (CBDCA) ligand connected to the atom at two different places. This ligand is harder to separate from the platinum atom than the chlorine atoms in cisplatin.[2]

Preparation

Carboplatin can be made from cisplatin or its chemical precursor, cis-diamminodiiodoplatinum, and a salt of 1,1-cyclobutane dicarboxylate.[source?]

References

  1. ↑ Lebwohl, D.; Canetta, R. (1998). "Clinical development of platinum complexes in cancer therapy: An historical perspective and an update". European Journal of Cancer. 34 (10): 1522–1534. doi:10.1016/S0959-8049(98)00224-X. PMID 9893623.
  2. ↑ Ciancetta, Antonella; Coletti, Cecilia; Marrone, Alessandro; Re, Nazzareno (2011). "Activation of carboplatin by chloride ions: A theoretical investigation". Theoretical Chemistry Accounts. 129 (6): 757–769. doi:10.1007/s00214-011-0933-9.




Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.