Ulp1 peptidaza

Ulp1 peptidaza
Identifikatori
EC broj	3.4.22.68
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Ulp1 peptidaza (EC 3.4.22.68, Smt3-protein konjugatna proteinaza, Ubl-specifična proteaza 1, Ulp1, Ulp1 endopeptidaza, Ulp1 proteaza) je enzim.^{[1][2][3][4][5][6]} Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza alfa-vezane peptidne veze u sekvenci Gly-Gly-Ala-Thr-Tyr na C-terminalnom kraju malog ubikvitinu sličnog modifikujućeg (SUMO) propeptid, Smt3, što dovodi do maturacije proteina. Druga reakcija je razlaganje epsilon-vezane peptidne veze između C-terminalnog glicina maturisanog SUMO i lizinske epsilon-amino grupe ciljnog proteina

Enzim iz Saccharomyces cerevisiae takođe može da prepozna mali ubikvitinu-sličan modifikator 1 (SUMO-1) ljudi kao supstrat.

Reference

1. Lima, C.D. (2004). „Ulp1 endopeptidase”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd izd.). London: Elsevier. str. 1340-1344. 
2. Li, S.-J. and Hochstrasser, M. (1999). „A new protease required for cell-cycle progression in yeast”. Nature 398: 246-251. PMID 10094048. 
3. Taylor, D.L., Ho, J.C., Oliver, A. and Watts, F.Z. (2002). „Cell-cycle-dependent localisation of Ulp1, a Schizosaccharomyces pombe Pmt3 (SUMO)-specific protease”. J. Cell Sci. 115: 1113-1122. PMID 11884512. 
4. Li, S.-J. and Hochstrasser, M. (2003). „The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity”. J. Cell Biol. 160: 1069-1081. PMID 12654900. 
5. Ihara, M., Koyama, H., Uchimura, Y., Saitoh, H. and Kikuchi, A. (2007). „Noncovalent binding of small ubiquitin-related modifier (SUMO) protease to SUMO is necessary for enzymatic activities and cell growth”. J. Biol. Chem. 282: 16465-16475. PMID 17428805. 
6. Mukhopadhyay, D. and Dasso, M. (2007). „Modification in reverse: the SUMO proteases”. Trends Biochem. Sci. 32: 286-295. PMID 17499995. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

• Lima, C.D. (2004). „Ulp1 endopeptidase”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd izd.). London: Elsevier. str. 1340-1344. 

Vanjske veze

• MeSH Ulp1+peptidase