Tetrahidrokanabinolinska kiselina sintaza

Tetrahidrokanabinolinska kiselina sintaza
Identifikatori
EC broj	1.21.3.7
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Tetrahidrokanabinolinska kiselina sintaza (EC 1.21.3.7, THCA sintaza, Delta1-tetrahidrokanabinolna kiselina sintaza) je enzim sa sistematskim imenom kanabigerolat:kiseonik oksidoreduktaza (ciklizacija, formira Delta9-tetrahidrokanabinolat).^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

kanabigerolat + O₂ ${\displaystyle \rightleftharpoons }$ Delta9-tetrahidrokanabinolat + H₂O₂

Ovaj enzim je flavoprotein (FAD). Kofaktor je kovalentno vezan.

Reference

1. Taura, F., Morimoto, S. Shoyama, Y. and Mechoulam, R. (1995). „First direct evidence for the mechanism of Δ¹-tetrahydrocannabinolic acid biosynthesis”. J. Am. Chem. Soc. 117: 9766-9767. 
2. Sirikantaramas, S., Morimoto, S., Shoyama, Y., Ishikawa, Y., Wada, Y., Shoyama, Y. and Taura, F. (2004). „The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of Δ¹-tetrahydrocannabinolic acid synthase from Cannabis sativa L”. J. Biol. Chem. 279: 39767-39774. PMID 15190053. 
3. Shoyama, Y., Takeuchi, A., Taura, F., Tamada, T., Adachi, M., Kuroki, R., Shoyama, Y. and Morimoto, S. (2005). „Crystallization of Δ¹-tetrahydrocannabinolic acid (THCA) synthase from Cannabis sativa”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61: 799-801. PMID 16511162. 
4. Shoyama, Y., Tamada, T., Kurihara, K., Takeuchi, A., Taura, F., Arai, S., Blaber, M., Shoyama, Y., Morimoto, S. and Kuroki, R. (2012). „Structure and function of 1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa”. J. Mol. Biol.: -. PMID 22766313. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Tetrahydrocannabinolic+acid+synthase