Taligluceraza alfa

Taligluceraza alfa
Klinički podaci
Robne marke Elelyso, UPLYSO
AHFS/Drugs.com alfa.html Monografija
Identifikatori
CAS broj 37228-64-1
ATC kod A16AB11
DrugBank DB08876
Hemijski podaci
Formula ?
Farmakokinetički podaci
Poluvreme eliminacije 18,9 - 28,7 min
Farmakoinformacioni podaci
Trudnoća ?
Pravni status
Način primene Intravenozno

Taligluceraza alfa (Elelyso) enzim je koji se proizvodi koristeći biljne ćelije.[1] Ovaj enzim je rekombinantna glukocerebrozidaza, koja se koristi za lečenje Gaučeve bolesti.[2][3][4][5] Ona je bila prvi lek biljnog porekla koji je FDA odobrila.[6][7] Izražavanje proteina u biljnim ćelijama je dovoljno visoko da nisu neophodna naknadne modifikacije proteina. Produkt nije podložan virusnoj kontaminaciji. Upotreva transgenskih ćelija šangarepe je jeftinija alternativa. Preklinička ispitivanja su pokazala da je enzim dobro tolerisan kod pacijenata.[8]

Reference

  1. Expanded Access Trial of Plant Expressed Recombinant Glucocerebrosidase (prGCD) in Patients With Gaucher Disease
  2. Zimran A, Brill-Almon E, Chertkoff R, Petakov M, Blanco-Favela F, Munoz ET, Solorio-Meza SE, Amato D, Duran G, Giona F, Heitner R, Rosenbaum H, Giraldo P, Mehta A, Park G, Phillips M, Elstein D, Altarescu G, Szleifer M, Hashmueli S, Aviezer D: Pivotal trial with plant cell-expressed recombinant glucocerebrosidase, taliglucerase alfa, a novel enzyme replacement therapy for Gaucher disease. Blood. 2011 Nov 24;118(22):5767-73. doi: 10.1182/blood-2011-07-366955. Epub 2011 Sep 6. PMID 21900191
  3. Aviezer D, Brill-Almon E, Shaaltiel Y, Hashmueli S, Bartfeld D, Mizrachi S, Liberman Y, Freeman A, Zimran A, Galun E: A plant-derived recombinant human glucocerebrosidase enzyme--a preclinical and phase I investigation. PLoS One. 2009;4(3):e4792. doi: 10.1371/journal.pone.0004792. Epub 2009 Mar 11. PMID 19277123
  4. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.  edit
  5. David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.  edit
  6. Is the Drought Over for Pharming
  7. Maxmen, Amy (2 may 2012) First plant-made drug on the market Arhivirano 2012-10-18 na Wayback Machine-u Nature, Biology & Biotechnology, Industry, Retrieved 26 June 2012
  8. Aviezer, D; Brill-Almon, E; Shaaltiel, Y; Hashmueli, S; Bartfeld, D; Mizrachi, S; Liberman, Y; Freeman, A i dr.. (2009). Ho, Paulo Lee. ur. „A Plant-Derived Recombinant Human Glucocerebrosidase Enzyme—A Preclinical and Phase I Investigation”. PLoS ONE 4 (3): e4792. DOI:10.1371/journal.pone.0004792. PMC 2652073. PMID 19277123. 

Literatura

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