TRNK (adenin-N1-)-metiltransferaza

TRNK (adenin-N1-)-metiltransferaza
Identifikatori
EC broj	2.1.1.36
CAS broj	37257-03-7
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

TRNK (adenin-N1-)-metiltransferaza (EC 2.1.1.36, transfer ribonukleat adeninska 1-metiltransferaza, transfer RNK (adenin-1) metiltransferaza, 1-metiladenin transfer RNK metiltransferaza, adenin-1-metilaza, S-adenozil-L-metionin:tRNK (adenin-1-N-)-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (adenin-N1-)-metiltransferaza.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + tRNK ${\displaystyle \rightleftharpoons }$ S-adenozil-L-homocistein + tRNK N1-metiladenin

Enzimi iz različitih izvora su specifični za različite adeninske ostatke u tRNK.

Reference

1. Baguley, B.C. and Staehelin, M. (1968). „The specificity of transfer ribonucleic acid methylases from rat liver”. Biochemistry 7: 45-50. PMID 4921283. 
2. Björk, G.R. and Svensson, I. (1969). „Studies on microbial RNA. Fractionation of tRNA methylases from Saccharomyces cerevisiae”. Eur. J. Biochem. 9: 207-215. PMID 4896260. 
3. Dubois, E.E., Dirheimer, G. and Weil, J.H. (1974). „Methylation of yeast tRNA Asp by enzymes from cytoplasm, chloroplasts and mitochondria of Phaseolus vulgaris”. Biochim. Biophys. Acta 374: 332-341. PMID 4611497. 
4. Glick, J.M. and Leboy, P.S. (1977). „Purification and properties of tRNA(adenine-1)-methyltransferase from rat liver”. J. Biol. Chem. 252: 4790-4795. PMID 17605. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH TRNA+(adenine-N1-)-methyltransferase