Serinska peptidaza ekvinskog arterivirusa

Serinska peptidaza ekvinskog arterivirusa
Identifikatori
EC broj	3.4.21.114
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Serinska peptidaza ekvinskog arterivirusa (EC 3.4.21.114, Equine arterivirus serine peptidase) je enzim.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Presecanje (Glu/Gln)-(Gly/Ser/Ala) u translacionim produktima arterivirusne replikaze ORF1a i ORF1ab

U konjskom arterivirusu (EAV), gen replikaze se translira u otvorene okvire čitanja 1a (ORF1a) i ORF1ab poliproteina.

Reference

1. Snijder, E.J., Wassenaar, A.L., van Dinten, L.C., Spaan, W.J. and Gorbalenya, A.E. (1996). „The arterivirus nsp4 protease is the prototype of a novel group of chymotrypsin-like enzymes, the 3C-like serine proteases”. J. Biol. Chem. 271: 4864-4871. PMID 8617757. 
2. van Dinten, L.C., Rensen, S., Gorbalenya, A.E. and Snijder, E.J. (1999). „Proteolytic processing of the open reading frame 1b-encoded part of arterivirus replicase is mediated by nsp4 serine protease and is essential for virus replication”. J. Virol. 73: 2027-2037. PMID 9971783. 
3. Barrette-Ng, I.H., Ng, K.K., Mark, B.L., Van Aken, D., Cherney, M.M., Garen, C., Kolodenko, Y., Gorbalenya, A.E., Snijder, E.J. and James, M.N. (2002). „Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an α/β C-terminal extension and alternate conformations of the oxyanion hole”. J. Biol. Chem. 277: 39960-39966. PMID 12163505. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Equine+arterivirus+serine+peptidase