Salutaridinol 7-O-acetiltransferaza

Salutaridinol 7-O-acetiltransferaza
Identifikatori
EC broj	2.3.1.150
CAS broj	156859-13-1
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Salutaridinol 7-O-acetiltransferaza (EC 2.3.1.150) je enzim sa sistematskim imenom acetil-KoA:salutaridinol 7-O-acetiltransferaza.^[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

acetil-KoA + salutaridinol ${\displaystyle \rightleftharpoons }$ KoA + 7-O-acetilsalutaridinol

Ovaj enzim je prisutan u maku, Papaver somniferum. Pri pH 8-9 produkt, 7-O-acetilsalutaridinol, spontano prelazi u 4->5 oksid uglavnom putem alilne eliminacije čime se formira morfinski prekurzor tebain.

Reference

1. Lenz, R., Zenk, M.H. (1994). „Closure of the oxide bridge in morphine biosynthesis”. Tetrahedron Lett. 35: 3897-3900. 
2. Lenz, R., Zenk, M.H. (1995). „Acetyl-CoA:salutaridinol 7-O-acetyltransferase from Papaver somniferum plant cell cultures. The enzyme catalyzing the formation of thebaine in morphine biosynthesis”. J. Biol. Chem. 270: 31091-31096. PMID 8537369. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Salutaridinol+7-O-acetyltransferase