Peptidaza mitohondrijalna prerade

Peptidaza mitohondrijalna prerade
Identifikatori
EC broj	3.4.24.64
CAS broj	86280-61-7
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Peptidaza mitohondrijalna prerade (EC 3.4.24.64, proteinaza transofmacije mitohondrijskog proteinskog prekursora, matriks peptidaza, matriks procesujuća peptidaza, matriks procesujuća proteinaza, proteinaza transformacije mitohondrijskog proteinskog prekursora, MPP) je enzim.^{[1][2][3][4][5]} Ovaj enzim katalizuje sledeću hemijsku reakciju

Oslobađanje N-terminalnog ciljnih peptida sa prekursornih proteina unesenih u mitohondrion, tipično sa Arg u poziciji P2

Ovaj enzim je prisutan u mitohondrijskom matriksu gljiva i sisara.

Reference

1. Jensen, R.E. and Yaffe, M.P. (1988). „Import of proteins into yeast mitochondria: the nuclear MAS2 gene encodes a component of the processing protease that is homologous to the MAS1-encoded subunit”. EMBO J. 7: 3863-3871. PMID 3061808. 
2. Witte, C., Jensen, R.E., Yaffe, M.P. and Schatz, G. (1988). „MAS1, a gene essential for yeast mitochondrial assembly, encodes a subunit of the mitochondrial processing protease”. EMBO J. 7: 1439-1447. PMID 3044780. 
3. Rawlings, N.D. and Barrett, A.J. (1991). „Homologues of insulinase, a new superfamily of metalloendopeptidases”. Biochem. J. 275: 389-391. PMID 2025223. 
4. Kalousek, F., Neupert, W., Omura, T., Schatz, G. and Schmitz, U.K. (1993). „Uniform nomenclature for the mitochondrial peptidases cleaving precursors of mitochondrial proteins”. Trends Biochem. Sci. 18: 249-249. PMID 8212133. 
5. Brunner, M. and Neupert, W. (1994). „Purification and characterization of the mitochondrial processing peptidase of Neurospora crassa”. Methods Enzymol. 248: 717-728. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Mitochondrial+processing+peptidase