Peptidaza C-terminalne obrade

Peptidaza C-terminalne obrade
Identifikatori
EC broj	3.4.21.102
CAS broj	92480-11-0&title= 216484-75-2, 92480-11-0
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Peptidaza C-terminalne obrade (EC 3.4.21.102, CtpA genski produkt (Synechocystis sp.), fotosistem II D1 protein obrade peptidaze, proteaza Re, proteaza specifična za rep, Tsp proteaza) je enzim.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Enzim specifično prepoznaje C-terminalni tripeptid, Xaa-Yaa-Zaa, u kome je Xaa preferentno Ala ili Leu, Yaa je preferentno Ala ili Tyr, i Zaa je preferentno Ala

Proteolitička obrada D1 proteina fotosistema II je neophodna da bi se omogućila svetlom rukovođeno formiranje tetranuklearnog manganskig klustera, koji je odgovoran za fotosintetičku oksidaciju vode.

Reference

1. Keiler, K.C. and Sauer, R.T. (1998). „Tsp protease”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Handbook of Proteolytic Enzymes. str. 460-461. 
2. Beebe, K.D., Shin, J.N., Peng, J., Chaudhury, C., Khera, J. and Pei, D.H. (2000). „Substrate recognition through a PDZ domain in tail-specific protease”. Biochemistry 39: 3149-3155. PMID 10715137. 
3. Liao, D.I., Qian, J., Chisholm, D.A., Jordan, D.B. and Diner, B.A. (2000). „Crystal structures of the photosystem II D1 C-terminal processing protease”. Nat. Struct. Biol. 7: 749-753. PMID 10966643. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

• Keiler, K.C. and Sauer, R.T. (1998). „Tsp protease”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Handbook of Proteolytic Enzymes. str. 460-461. 

Vanjske veze

• MeSH C-terminal+processing+peptidase