Nitrit reduktaza (formira NO)

Nitrit reduktaza (formira NO)
Trimer nitrit reduktaze (Alcaligenes faecalis)
Identifikatori
EC broj	1.7.2.1
CAS broj	2622511
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Nitrit reduktaza (formira NO) (EC 1.7.2.1, cd-citohrom nitritna reduktaza, citohrom c-551:O2, NO²⁺ oksidoreduktaza, citohrom cd, citohrom cd1, hidroksilamin (akceptor) reduktaza, metil viologen-nitritna reduktaza, nitritna reduktaza (citohrom, formira NO)) je enzim sa sistematskim imenom nitric-oksid:fericitohrom-c oksidoreduktaza.^{[1][2][3][4][5][6][7][8][9][10][11]} Ovaj enzim katalizuje sledeću hemijsku reakciju

Azot monoksid +H₂O + fericitohrom c ${\displaystyle \rightleftharpoons }$ nitrit + ferocitohrom c + 2 H⁺

Ovu reakciju katalizuju dva tipa enzima, koji su prisutni u perimplazmi denitrifikacionih bakterija. Jedan tip obuhvata proteine koji sadrže višestruke bakarne centre, dok su enzimi drugog tipa hem proteini sa citohromom cd1.

Reference

1. Miyata, M. and Mori, T. (1969). „S'tudies on denitrification. X. The "denitrifying enzyme" as a nitrite reductase and the electron donating system for denitrification”. J. Biochem. (Tokyo) 66: 463-471. PMID 5354021. 
2. Chung, C.W. and Najjar, V.A. (1956). „Cofactor requirements for enzymatic denitrification. I. Nitrite reductase”. J. Biol. Chem. 218: 617-625. PMID 13295215. 
3. Walker, G.C. and Nicholas, D.J.D. (1961). „Nitrite reductase from Pseudomonas aeruginosa”. Biochim. Biophys. Acta 49: 350-360. PMID 13782716. 
4. Singh, J. (1974). „Cytochrome oxidase from Pseudomonas aeruginosa. III. Reduction of hydroxylamine”. Biochim. Biophys. Acta 333: 28-36. 
5. Michalski, W.P. and Nicholas, D.J.D. (1985). „Molecular characterization of a copper-containing nitrite reductase from Rhodopseudomonas sphaeriodes forma sp. Denitrificans”. Biochim. Biophys. Acta 828: 130-137. 
6. Godden, J.W., Turley, S., Teller, D.C., Adman, E.T., Liu, M.Y., Payne, W.J. and Legall, J. (1991). „The 2.3 angstrom X-ray structure of nitrite reductase from Achromobacter cycloclastes”. Science 253: 438-442. PMID 1862344. 
7. Williams, P.A., Fulop, V., Leung, Y.C., Chan, C., Moir, J.W.B., Howlett, G., Ferguson, S.J., Radford, S.E. and Hajdu, J. (1995). „Pseudospecific docking surfaces on electron transfer proteins as illustrated by pseudoazurin, cytochrome c-550 and cytochrome cd1 nitrite reductase”. Nat. Struct. Biol. 2: 975-982. PMID 7583671. 
8. Hole, U.H., Vollack, K.U., Zumft, W.G., Eisenmann, E., Siddiqui, R.A., Friedrich, B. and Kroneck, P.M.H. (1996). „Characterization of the membranous denitrification enzymes nitrite reductase (cytochrome cd1) and copper-containing nitrous oxide reductase from Thiobacillus denitrificans”. Arch. Microbiol. 165: 55-61. PMID 8639023. 
9. Zumft, W.G. (1997). „Cell biology and molecular basis of denitrification”. Microbiol. Mol. Biol. Rev. 61: 533-616. PMID 9409151. 
10. Ferguson, S.J. (1998). „Nitrogen cycle enzymology”. Curr. Opin. Chem. Biol. 2: 182-193. PMID 9667932. 
11. Vijgenboom, E., Busch, J.E. and Canters, G.W. (1997). „In vitro studies disprove the obligatory role of azurin in denitrification in Pseudomonas aeruginosa and show that azu expression is under the control of RpoS and ANR”. Microbiology 143: 2853-2863. PMID 9308169. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Nitrite+reductase+(NO-forming)