NADH:ubihinon reduktaza (neelektrogena)

NADH:ubihinon reduktaza (neelektrogena)
Identifikatori
EC broj	1.6.5.9
CAS broj	9028-04-0
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

NADH:ubihinon reduktaza (neelektrogena) (EC 1.6.5.9, ubihinonska reduktaza, koenzim Q reduktaza, dihidronikotinamid adenin dinukleotid-koenzim Q reduktaza, DPNH-koenzim Q reduktaza, DPNH-ubihinon reduktaza, NADH-koenzim Q oksidoreduktaza, NADH-koenzim Q reduktaza, NADH-CoQ oksidoreduktaza, NADH-CoQ reduktaza, NADH-ubihinonska reduktaza, NADH-ubihinonska oksidoreduktaza, redukovani nikotinamid adenin dinukleotid-koenzim Q reduktaza, NADH-Q6 oksidoreduktaza, kompleks transfera elektrona I, NADH2 dehidrogenaza (ubihinon)) je enzim sa sistematskim imenom NADH:ubihinon oksidoreduktaza.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

NADH + H⁺ + ubihinon ${\displaystyle \rightleftharpoons }$ NAD⁺ + ubihinol

Ovaj enzim je flavoprotein (FAD). On se javlja u mitohondrijama kvasaca i biljki, i u aerobnim bakterijama.

Reference

1. Moller, I.M, and Palmer, J.M. (1982). „Direct evidence for the presence of a rotenone-resistant NADH dehydrogenase on the inner surface of plant mitochondria”. Physiologia Plantarum 54: 267-274. 
2. de Vries, S. and Grivell, L.A. (1988). „Purification and characterization of a rotenone-insensitive NADH:Q6 oxidoreductase from mitochondria of Saccharomyces cerevisiae”. Eur. J. Biochem. 176: 377-384. PMID 3138118. 
3. Kerscher, S.J., Okun, J.G. and Brandt, U. (1999). „A single external enzyme confers alternative NADH:ubiquinone oxidoreductase activity in Yarrowia lipolytica”. J. Cell Sci. 112 ( Pt 14): 2347-2354. PMID 10381390. 
4. Rasmusson, A.G., Soole, K.L. and Elthon, T.E. (2004). „Alternative NAD(P)H dehydrogenases of plant mitochondria”. Annu. Rev. Plant Biol. 55: 23-39. PMID 15725055. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH NADH:ubiquinone+reductase+(non-electrogenic)