Malonil-S-ACP dekarboksilaza

Malonil-S-ACP dekarboksilaza
Identifikatori
EC broj	4.1.1.87
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Malonil-S-ACP dekarboksilaza (EC 4.1.1.87, malonil-S-acil-nosilac protein dekarboksilaza, MdcD/MdcE, MdcD,E) je enzim sa sistematskim imenom malonil-(acil-nosilac-protein) karboksilijaza.^{[1][2][3][4][5]} Ovaj enzim katalizuje sledeću hemijsku reakciju

malonil-[acil-nosilac protein] + H⁺ ${\displaystyle \rightleftharpoons }$ acetil-[acil-nosilac protein] + CO₂

Ovaj enzim se sastoji od beta i gama podjecinice enzima EC 4.1.1.88.

Reference

1. Schmid, M., Berg, M., Hilbi, H. and Dimroth, P. (1996). „Malonate decarboxylase of Klebsiella pneumoniae catalyses the turnover of acetyl and malonyl thioester residues on a coenzyme-A-like prosthetic group”. Eur. J. Biochem. 237: 221-228. PMID 8620876. 
2. Koo, J.H. and Kim, Y.S. (1999). „Functional evaluation of the genes involved in malonate decarboxylation by Acinetobacter calcoaceticus”. Eur. J. Biochem. 266: 683-690. PMID 10561613. 
3. Handa, S., Koo, J.H., Kim, Y.S. and Floss, H.G. (1999). „Stereochemical course of biotin-independent malonate decarboxylase catalysis”. Arch. Biochem. Biophys. 370: 93-96. PMID 10496981. 
4. Chohnan, S., Akagi, K. and Takamura, Y. (2003). „Functions of malonate decarboxylase subunits from Pseudomonas putida”. Biosci. Biotechnol. Biochem. 67: 214-217. PMID 12619701. 
5. Dimroth, P. and Hilbi, H. (1997). „Enzymic and genetic basis for bacterial growth on malonate”. Mol. Microbiol. 25: 3-10. PMID 11902724. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Malonyl-S-ACP+decarboxylase