Luteolin O-metiltransferaza

Luteolin O-metiltransferaza
Identifikatori
EC broj	2.1.1.42
CAS broj	37205-55-3
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Luteolin O-metiltransferaza (EC 2.1.1.42, o-dihidro fenolna metiltransferaza, luteolinska metiltransferaza, luteolinska 3'-O-metiltransferaza, o-difenolna m-O-metiltransferaza, o-dihidro fenol meta-O-metiltransferaza, S-adenozilmetionin:flavon/flavonol 3'-O-metiltransferaza, kvercetin 3'-O-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:3'-hidroksiflavon 3'-O-metiltransferaza.^{[1][2][3][4][5]} Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + 3'-hidroksiflavon ${\displaystyle \rightleftharpoons }$ S-adenozil-L-homocistein + 3'-metoksiflavon

Ovaj enzim preferira flavone sa vicinalnim 3',4'-dihidroksilnim grupama.

Reference

1. Ebel, J., Hahlbrock, K. and Grisebach, H. (1972). „Purification and properties of an o-dihydricphenol meta-O-methyltransferase from cell suspension cultures of parsley and its relation to flavonoid biosynthesis”. Biochim. Biophys. Acta 268: 313-326. PMID 5026305. 
2. Muzac, I., Wang, J., Anzellotti, D., Zhang, H. and Ibrahim, R.K. (2000). „Functional expression of an Arabidopsis cDNA clone encoding a flavonol 3′-O-methyltransferase and characterization of the gene product”. Arch. Biochem. Biophys. 375: 385-388. PMID 10700397. 
3. Poulton, J.E., Hahlbrock, K. and Grisebach, H. (1977). „O-Methylation of flavonoid substrates by a partially purified enzyme from soybean cell suspension cultures”. Arch. Biochem. Biophys. 180: 543-549. PMID 18099. 
4. Kim, B.G., Lee, H.J., Park, Y., Lim, Y. and Ahn, J.H. (2006). „Characterization of an O-methyltransferase from soybean”. Plant Physiol. Biochem. 44: 236-241. PMID 16777424. 
5. Lee, Y.J., Kim, B.G., Chong, Y., Lim, Y. and Ahn, J.H. (2008). „Cation dependent O-methyltransferases from rice”. Planta 227: 641-647. PMID 17943312. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Flavone+3'-O-methyltransferase