Inozitol-polifosfat multikinaza

Inozitol-polifosfat multikinaza
Identifikatori
EC broj	2.7.1.151
CAS broj	9077-69-4
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Inozitol-polifosfat multikinaza (EC 2.7.1.151, IpK2, IP3/IP4 6-/3-kinaza, IP3/IP4 dualno-specifična 6-/3-kinaza, IpmK, ArgRIII, AtIpk2alfa, AtIpk2beta, inozitol polifosfatna 6-/3-/5-kinaza) je enzim sa sistematskim imenom ATP:1D-mio-inozitol-1,4,5-trisfosfat 6-fosfotransferaza.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

2 ATP + 1D-mio-inozitol 1,4,5-trisfosfat ${\displaystyle \rightleftharpoons }$ 2 ADP + 1D-mio-inozitol 1,3,4,5,6-pentakisfosfat (sveukupna reakcija)

(1a) ATP + 1D-mio-inozitol 1,4,5-trisfosfat ${\displaystyle \rightleftharpoons }$ ADP + 1D-mio-inozitol 1,4,5,6-tetrakisfosfat

(1b) ATP + 1D-mio-inozitol 1,4,5,6-tetrakisfosfat ${\displaystyle \rightleftharpoons }$ ADP + 1D-mio-inozitol 1,3,4,5,6-pentakisfosfat

Ovaj enzim takođe fosforiliše Ins(1,4,5)P3 do Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 do Ins(1,3,4,5,6)P5, i Ins(1,3,4,5,6)P4 do Ins(PP)P4, nepoznatog izomera.

Reference

1. Saiardi, A., Erdjument-Bromage, H., Snowman, A.M., Tempst, P. and Snyder, S.H. (1999). „Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases”. Curr. Biol. 9: 1323-1326. PMID 10574768. 
2. Odom, A.R., Stahlberg, A., Wente, S.R. and York, J.D. (2000). „A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control”. Science 287: 2026-2029. PMID 10720331. 
3. Stevenson-Paulik, J., Odom, A.R. and York, J.D. (2002). „Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases”. J. Biol. Chem. 277: 42711-42718. PMID 12226109. 
4. Verbsky, J.W., Chang, S.C., Wilson, M.P., Mochizuki, Y. and Majerus, P.W. (2005). „The pathway for the production of inositol hexakisphosphate in human cells”. J. Biol. Chem. 280: 1911-1920. PMID 15531582. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Inositol-polyphosphate+multikinase