Hormon-senzitivna lipaza

Hormon-senzitivna lipaza
Identifikatori
EC broj	3.1.1.79
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Hormon-senzitivna lipaza (EC 3.1.1.79, HSL) je enzim sa sistematskim imenom diacilglicerol acilhidrolaza.^{[1][2][3][4][5][6][7][8]} Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) diacilglicerol + H₂O ${\displaystyle \rightleftharpoons }$ monoacilglicerol + karboksilat

(2) triacilglicerol + H₂O ${\displaystyle \rightleftharpoons }$ diacilglicerol + karboksilat

(3) monoacilglicerol + H₂O ${\displaystyle \rightleftharpoons }$ glicerol + karboksilat

Ovaj enzim je serinska hidrolaza.

Reference

1. Holm, C., Osterlund, T., Laurell, H. and Contreras, J.A. (2000). „Molecular mechanisms regulating hormone-sensitive lipase and lipolysis”. Annu. Rev. Nutr. 20: 365-393. PMID 10940339. 
2. Fredrikson, G., Stralfors, P., Nilsson, N.O. and Belfrage, P. (1981). „Hormone-sensitive lipase of rat adipose tissue. Purification and some properties”. J. Biol. Chem. 256: 6311-6320. PMID 7240206. 
3. Vaughan, M., Berger, J.E. and Steinberg, D. (1964). „Hormone-sensitive lipase and monoglyceride lipase activities in adipose tissue”. J. Biol. Chem. 239: 401-409. PMID 14169138. 
4. Østerlund, T., Danielsson, B., Degerman, E., Contreras, J.A., Edgren, G., Davis, R.C., Schotz, M.C. and Holm, C. (1996). „Domain-structure analysis of recombinant rat hormone-sensitive lipase”. Biochem. J. 319 ( Pt 2): 411-420. PMID 8912675. 
5. Lee, F.T., Adams, J.B., Garton, A.J. and Yeaman, S.J. (1988). „Hormone-sensitive lipase is involved in the hydrolysis of lipoidal derivatives of estrogens and other steroid hormones”. Biochim. Biophys. Acta 963: 258-264. PMID 3196730. 
6. Wei, S., Lai, K., Patel, S., Piantedosi, R., Shen, H., Colantuoni, V., Kraemer, F.B. and Blaner, W.S. (1977). „Retinyl ester hydrolysis and retinol efflux from BFC-1β adipocytes”. J. Biol. Chem. 272: 14159-14165. PMID 9162045. 
7. Tsujita, T., Ninomiya, H. and Okuda, H. (1989). „p-Nitrophenyl butyrate hydrolyzing activity of hormone-sensitive lipase from bovine adipose tissue”. J. Lipid Res. 30: 997-1004. PMID 2794798. 
8. Yeaman, S.J. (2004). „Hormone-sensitive lipase - new roles for an old enzyme”. Biochem. J. 379: 11-22. PMID 14725507. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Hormone-sensitive+lipase