Dimetilsulfoksid reduktaza

Dimetilsulfoksid reduktaza
Identifikatori
EC broj	1.8.5.3
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Dimetilsulfoksid reduktaza (EC 1.8.5.3, DMSO reduktaza) je enzim sa sistematskim imenom dimetil sulfid:menahinon oksidoreduktaza.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

dimetilsulfid + menahinon +H₂O ${\displaystyle \rightleftharpoons }$ dimetilsulfoksid + menahinol

Ovaj enzim je molibdopterin. On sadrži [4Fe-4S] klastere. Ovaj enzim takođe redukuje piridin N-oksid i trimetilamin N-oksid.

Reference

1. Simala-Grant, J.L. and Weiner, J.H. (1996). „Kinetic analysis and substrate specificity of Escherichia coli dimethyl sulfoxide reductase”. Microbiology 142: 3231-3239. PMID 8969520. 
2. Daruwala, R. and Meganathan, R. (1991). „Dimethyl sulfoxide reductase is not required for trimethylamine N-oxide reduction in Escherichia coli”. FEMS Microbiol. Lett. 67: 255-259. PMID 1769531. 
3. Miguel, L. and Meganthan, R. (1991). „Electron donors and the quinone involved in dimethyl sulfoxide reduction in Escherichia coli”. Curr. Microbiol. 22: 109-115. 
4. Rothery, R.A., Trieber, C.A. and Weiner, J.H. (1999). „Interactions between the molybdenum cofactor and iron-sulfur clusters of Escherichia coli dimethylsulfoxide reductase”. J. Biol. Chem. 274: 13002-13009. PMID 10224050. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Dimethylsulfoxide+reductase