DTDP-4-amino-4,6-didezoksigalaktoza transaminaza

DTDP-4-amino-4,6-didezoksigalaktoza transaminaza
Identifikatori
EC broj	2.6.1.59
CAS broj	72560-97-5
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

DTDP-4-amino-4,6-didezoksigalaktoza transaminaza (EC 2.6.1.59, timidin difosfoaminodidezoksigalaktoza aminotransferaza, timidin difosfat 4-keto-6-dezoksi-D-glukoza transaminaza, WecE, dTDP-4,6-didezoksi-D-galaktoza:2-oksoglutarat aminotransferaza) je enzim sa sistematskim imenom dTDP-4,6-didezoksi-alfa-D-galaktoza:2-oksoglutarat aminotransferaza.^[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

dTDP-4-amino-4,6-didezoksi-alfa-D-galaktoza + 2-oksoglutarat ${\displaystyle \rightleftharpoons }$ dTDP-4-dehidro-6-dezoksi-alfa-D-galaktoza + L-glutamat

Ovaj enzim je piridoksal-fosfatni protein.

Reference

1. Ohashi, H., Matsuhashi, M. and Matsuhashi, S. (1971). „Thymidine diphosphate 4-acetamido-4,6-dideoxyhexoses. IV. Purification and properties of thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase from Pasteurella pseudotuberculosis”. J. Biol. Chem. 246: 2325-2330. PMID 4928644. 
2. Hwang, B.Y., Lee, H.J., Yang, Y.H., Joo, H.S. and Kim, B.G. (2004). „Characterization and investigation of substrate specificity of the sugar aminotransferase WecE from E. coli K12”. Chem. Biol. 11: 915-925. PMID 15271350. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH DTDP-4-amino-4,6-dideoxygalactose+transaminase