DNK oksidativna demetilaza

DNK oksidativna demetilaza
Identifikatori
EC broj	1.14.11.33
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

DNK oksidativna demetilaza (EC 1.14.11.33, protein popravke alkilisane DNK, alfa-ketoglutarat-zavisna dioksigenaza ABH1, alkB (gen)) je enzim sa sistematskim imenom metil DNA-base, 2-oksoglutarat:kiseonik oksidoreduktaza (formira formaldehid).^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

DNK-baza-CH_{3 + 2-oksoglutarat + O2 ${\displaystyle \rightleftharpoons }$ DNK-baza + formaldehid + sukcinat + CO2}

Ovaj enzim sadrži gvožđe. Njegovo dejstvo u maloj meri stimuliše askorbat.

Reference

1. Falnes, P.O., Johansen, R.F. and Seeberg, E. (2002). „AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli”. Nature 419: 178-182. PMID 12226668. 
2. Yi, C., Yang, C.G. and He, C. (2009). „A non-heme iron-mediated chemical demethylation in DNA and RNA”. Acc. Chem. Res. 42: 519-529. PMID 19852088. 
3. Yi, C., Jia, G., Hou, G., Dai, Q., Zhang, W., Zheng, G., Jian, X., Yang, C.G., Cui, Q. and He, C. (2010). „Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase”. Nature 468: 330-333. PMID 21068844. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH DNA+oxidative+demethylase