Alkohol dehidrogenaza (hinon)

Alkohol dehidrogenaza (hinon)
Identifikatori
EC broj	1.1.5.5
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Alkohol dehidrogenaza (hinon) (EC 1.1.5.5, tip III ADH, membranska hinohemoproteinska alkoholna dehidrogenaza) je enzim sa sistematskim imenom alkohol:hinon oksidoreduktaza.^{[1][2][3][4][5][6][7][8][9]} Ovaj enzim katalizuje sledeću hemijsku reakciju

etanol+ ubihinon ${\displaystyle \rightleftharpoons }$ acetaldehid + ubihinol

Ovaj enzim je prisutan kod bakterija sirćetne kiseline, kod kojih učestvuje u formiranju kiseline.

Reference

1. Gomez-Manzo, S., Contreras-Zentella, M., Gonzalez-Valdez, A., Sosa-Torres, M., Arreguin-Espinoza, R. and Escamilla-Marvan, E. (2008). „The PQQ-alcohol dehydrogenase of Gluconacetobacter diazotrophicus”. Int. J. Food Microbiol. 125: 71-78. PMID 18321602. 
2. Shinagawa, E., Toyama, H., Matsushita, K., Tuitemwong, P., Theeragool, G. and Adachi, O. (2006). „A novel type of formaldehyde-oxidizing enzyme from the membrane of Acetobacter sp. SKU 14”. Biosci. Biotechnol. Biochem. 70: 850-857. PMID 16636451. 
3. Chinnawirotpisan, P., Theeragool, G., Limtong, S., Toyama, H., Adachi, O.O. and Matsushita, K. (2003). „Quinoprotein alcohol dehydrogenase is involved in catabolic acetate production, while NAD-dependent alcohol dehydrogenase in ethanol assimilation in Acetobacter pasteurianus SKU1108”. J. Biosci. Bioeng. 96: 564-571. PMID 16233574. 
4. Frebortova, J., Matsushita, K., Arata, H. and Adachi, O. (1998). „Intramolecular electron transport in quinoprotein alcohol dehydrogenase of Acetobacter methanolicus: a redox-titration stud”. Biochim. Biophys. Acta 1363: 24-34. PMID 9526036. 
5. Matsushita, K., Kobayashi, Y., Mizuguchi, M., Toyama, H., Adachi, O., Sakamoto, K. and Miyoshi, H. (2008). „A tightly bound quinone functions in the ubiquinone reaction sites of quinoprotein alcohol dehydrogenase of an acetic acid bacterium, Gluconobacter suboxydans”. Biosci. Biotechnol. Biochem. 72: 2723-2731. PMID 18838797. 
6. Matsushita, K., Yakushi, T., Toyama, H., Shinagawa, E. and Adachi, O. (1996). „Function of multiple heme c moieties in intramolecular electron transport and ubiquinone reduction in the quinohemoprotein alcohol dehydrogenase-cytochrome c complex of Gluconobacter suboxydans”. J. Biol. Chem. 271: 4850-4857. PMID 8617755. 
7. Matsushita, K., Takaki, Y., Shinagawa, E., Ameyama, M. and Adachi, O. (1992). „Ethanol oxidase respiratory chain of acetic acid bacteria. Reactivity with ubiquinone of pyrroloquinoline quinone-dependent alcohol dehydrogenases purified from Acetobacter aceti and Gluconobacter suboxydans”. Biosci. Biotechnol. Biochem. 56: 304-310. 
8. Matsushita, K., Toyama, H. and Adachi, O. (1994). „Respiratory chains and bioenergetics of acetic acid bacteria”. Adv. Microb. Physiol. 36: 247-301. PMID 7942316. 
9. Cozier, G.E., Giles, I.G. and Anthony, C. (1995). „The structure of the quinoprotein alcohol dehydrogenase of Acetobacter aceti modelled on that of methanol dehydrogenase from Methylobacterium extorquens”. Biochem. J. 308: 375-379. PMID 7772016. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Alcohol+dehydrogenase+(quinone)