4-Aminobutirat—piruvat transaminaza

4-aminobutirat---piruvat transaminaza
Identifikatori
EC broj	2.6.1.96
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

4-aminobutirat---piruvat transaminaza (EC 2.6.1.96, aminobutiratna aminotransferaza, gama-aminobutiratna aminotransaminaza, gama-aminobutiratna transaminaza, gama-aminobutirno kiselinskaa aminotransferaza, gama-aminobutirna kiselina piruvatna transaminaza, gama-aminobutirna kiselina transaminaza, gama-aminobutirna transaminaza, 4-aminobutiratna aminotransferaza, 4-aminobutirna kiselina aminotransferaza, aminobutiratna transaminaza, GABA aminotransferaza, GABA transaminaza, GABA transferaza, POP2 (gen)) je enzim sa sistematskim imenom 4-aminobutanoat:piruvat aminotransferaza.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) 4-aminobutanoat + piruvat ${\displaystyle \rightleftharpoons }$ sukcinat semialdehid + L-alanin

(2) 4-aminobutanoat + glioksilat ${\displaystyle \rightleftharpoons }$ sukcinat semialdehid + glicin

Za rad ovog enzima je neophodan piridoksal 5'-fosfat.

Reference

1. Van Cauwenberghe, O.R. and Shelp, B.J. (1999). „Biochemical characterization of partially purified gaba:pyruvate transaminase from Nicotiana tabacum”. Phytochemistry 52: 575-581. 
2. Palanivelu, R., Brass, L., Edlund, A.F. and Preuss, D. (2003). „Pollen tube growth and guidance is regulated by POP2, an Arabidopsis gene that controls GABA levels”. Cell 114: 47-59. PMID 12859897. 
3. Clark, S.M., Di Leo, R., Dhanoa, P.K., Van Cauwenberghe, O.R., Mullen, R.T. and Shelp, B.J. (2009). „Biochemical characterization, mitochondrial localization, expression, and potential functions for an Arabidopsis γ-aminobutyrate transaminase that utilizes both pyruvate and glyoxylate”. J. Exp. Bot. 60: 1743-1757. PMID 19264755. 
4. Clark, S.M., Di Leo, R., Van Cauwenberghe, O.R., Mullen, R.T. and Shelp, B.J. (2009). „Subcellular localization and expression of multiple tomato γ-aminobutyrate transaminases that utilize both pyruvate and glyoxylate”. J. Exp. Bot. 60: 3255-3267. PMID 19470656. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH 4-aminobutyrate---pyruvate+transaminase