23S rRNK pseudouridinska746 sintaza

23S rRNK pseudouridinska^746 sintaza
Identifikatori
EC broj	5.4.99.29
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

23S rRNK pseudouridinska⁷⁴⁶ sintaza (EC 5.4.99.29, RluA, 23S RNK PSI⁷⁴⁶ sintaza, 23S rRNK pseudouridin sintaza, pseudouridin sintaza RluA) je enzim sa sistematskim imenom 23S rRNK-uridin⁷⁴⁶ uracil mutaza.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

23S rRNK uridin⁷⁴⁶ ${\displaystyle \rightleftharpoons }$ 23S rRNK pseudouridin⁷⁴⁶

RluA je jedini protein odgovoran za in vivo formiranje pseudouridina⁷⁴⁶ u 23S RNK.

Reference

1. Hoang, C., Chen, J., Vizthum, C.A., Kandel, J.M., Hamilton, C.S., Mueller, E.G. and Ferre-D'Amare, A.R. (2006). „Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure”. Mol. Cell 24: 535-545. PMID 17188032. 
2. Raychaudhuri, S., Niu, L., Conrad, J., Lane, B.G. and Ofengand, J. (1999). „Functional effect of deletion and mutation of the Escherichia coli ribosomal RNA and tRNA pseudouridine synthase RluA”. J. Biol. Chem. 274: 18880-18886. PMID 10383384. 
3. Wrzesinski, J., Nurse, K., Bakin, A., Lane, B.G. and Ofengand, J. (1995). „A dual-specificity pseudouridine synthase: an Escherichia coli synthase purified and cloned on the basis of its specificity for Ψ⁷⁴⁶ in 23S RNA is also specific for Ψ³² in tRNA^Phe”. RNA 1: 437-448. PMID 7493321. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH 23S+rRNA+pseudouridine746+synthase