2-Metilizoborneolna sintaza

2-Metilizoborneolna sintaza
Identifikatori
EC broj	4.2.3.118
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

2-Metilizoborneolna sintaza (EC 4.2.3.118, sco7700, 2-MIB ciklaza, MIB sintaza, MIBS) je enzim sa sistematskim imenom (E)-2-metilgeranil-difosfat difosfat-lijaza (ciklizacija, formira 2-metilizoborneol).^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

(E)-2-metilgeranil difosfat + H₂O ${\displaystyle \rightleftharpoons }$ 2-metilizoborneol + difosfat

Produkat, 2-metilizoborneol, je karakteristično jedinjenje ustajalog mirisa koje otpuštaju zemljišni mikroorganizmi.

Reference

1. Wang, C.M. and Cane, D.E. (2008). „Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor”. J. Am. Chem. Soc. 130: 8908-8909. PMID 18563898. 
2. Komatsu, M., Tsuda, M., Omura, S., Oikawa, H. and Ikeda, H. (2008). „Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol”. Proc. Natl. Acad. Sci. USA 105: 7422-7427. PMID 18492804. 
3. Giglio, S., Chou, W.K., Ikeda, H., Cane, D.E. and Monis, P.T. (2011). „Biosynthesis of 2-methylisoborneol in cyanobacteria”. Environ. Sci. Technol. 45: 992-998. PMID 21174459. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH 2-methylisoborneol+synthase