2,6-Dihidroksipseudooksinikotinska hidrolaza

2,6-Dihidroksipseudooksinikotinska hidrolaza
Identifikatori
EC broj 3.7.1.19
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

2,6-Dihidroksipseudooksinikotinska hidrolaza (EC 3.7.1.19) je enzim sa sistematskim imenom 1-(2,6-dihidroksipiridin-3-il)-4-(metilamino)butan-1-on hidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

1-(2,6-dihidroksipiridin-3-il)-4-(metilamino)butan-1-on + H2O 2,6-dihidroksipiridin + 4-metilaminobutanoat

Ovaj enzim je izolovan iz zemljišne bakterije Arthrobacter nikotinovorans.

Reference

  1. Gherna, R.L., Richardson, S.H. and Rittenberg, S.C. (1965). „The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine”. J. Biol. Chem. 240: 3669-3674. PMID 5835946. 
  2. Sachelaru, P., Schiltz, E., Igloi, G.L. and Brandsch, R. (2005). „An α/β-fold C–C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans. J. Bacteriol. 187: 8516-8519. PMID 16321959. 

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