16S rRNK pseudouridinska516 sintaza

16S rRNK pseudouridinska^516 sintaza
Identifikatori
EC broj	5.4.99.19
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

16S rRNK pseudouridinska516 sintaza (EC 5.4.99.19, 16S RNK pseudouridinska⁵¹⁶ sintaza, 16S PsiI⁵¹⁶ sintaza, 16S RNK Psi⁵¹⁶ sintaza, RNK pseudouridinska sintaza RsuA, RsuA, 16S RNK pseudouridin 516 sintaza) je enzim sa sistematskim imenom 16S rRNK-uridin⁵¹⁶ uracil mutaza.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

16S rRNK uridin⁵¹⁶ ${\displaystyle \rightleftharpoons }$ 16S rRNK pseudouridin⁵¹⁶

Ovaj enzim je specifičan za uridin⁵¹⁶ u 16S rRNK.

Reference

1. Wrzesinski, J., Bakin, A., Nurse, K., Lane, B.G. and Ofengand, J. (1995). „Purification, cloning, and properties of the 16S RNA pseudouridine 516 synthase from Escherichia coli”. Biochemistry 34: 8904-8913. PMID 7612632. 
2. Conrad, J., Niu, L., Rudd, K., Lane, B.G. and Ofengand, J. (1999). „16S ribosomal RNA pseudouridine synthase RsuA of Escherichia coli: deletion, mutation of the conserved Asp¹⁰² residue, and sequence comparison among all other pseudouridine synthases”. RNA 5: 751-763. PMID 10376875. 
3. Sivaraman, J., Sauve, V., Larocque, R., Stura, E.A., Schrag, J.D., Cygler, M. and Matte, A. (2002). „Structure of the 16S rRNA pseudouridine synthase RsuA bound to uracil and UMP”. Nat. Struct. Biol. 9: 353-358. PMID 11953756. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH 16S+rRNA+pseudouridine516+synthase