15-Oksoprostaglandin 13-oksidaza

15-oksoprostaglandin 13-oksidaza
Identifikatori
EC broj	1.3.1.48
CAS broj	57406-74-3
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

15-oksoprostaglandin 13-oksidaza (EC 1.3.1.48, 15-okso-Delta13-prostaglandin reduktaza, Delta13-15-ketoprostaglandinska reduktaza, 15-ketoprostaglandinska Delta13-reduktaza, prostaglandinska Delta13-reduktaza, prostaglandinska 13-reduktaza, 15-ketoprostaglandinska Delta13-reduktaza, (5Z)-(15S)-11alfa-hidroksi-9,15-dioksoprostanoat:NAD(P)⁺ Delta13-oksidoreduktaza, (5Z)-11alfa-hidroksi-9,15-dioksoprost-5-enoat:NAD(P)⁺ Delta13-oksidoreduktaza) je enzim sa sistematskim imenom 11alfa-hidroksi-9,15-dioksoprostanoat:NAD(P)⁺ Delta13-oksidoreduktaza.^[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

11alfa-hidroksi-9,15-dioksoprostanoat + NAD(P)⁺ ${\displaystyle \rightleftharpoons }$ (13E)-11alfa-hidroksi-9,15-dioksoprost-13-enoat + NAD(P)H + H⁺

Ovaj enzim redukuje 15-oksoprostaglandine do 13,14-dihidro derivata. Enzim iz materice je specifičan za NAD⁺.

Reference

1. Hansen, H.S. (1982). „Purification and assay of 15-ketoprostaglandin Δ¹³-reductase from bovine lung”. Methods Enzymol. 86: 156-163. PMID 6290839. 
2. Jarabak, J. (1982). „Isolation and properties of a 15-ketoprostaglandin Δ¹³-reductase from human placenta”. Methods Enzymol. 86: 163-167. PMID 7132753. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH 15-oxoprostaglandin+13-oxidase