Morando numa Boston suburbana, Louis demonstrou o desejo em se tornar comediante e roteirista, citando Richard Pryor, Steve Martin e George Carlin como algumas de suas influências. Quando tinha dez anos de idade, seus pais se divorciaram, e Louis foi morar, junto de suas irmãs, com sua mãe em Newton, Massachusetts.
Antes do sucesso, Louis trabalhou como roteirista para diversos programas na televisão como: The Late Show with David Letterman, Late Night with Conan O'Brien, The Dana Carvey Show, e The Chris Rock Show.
Louis e pintora Alix Bailey casaram-se em 1995. Juntos, eles tiveram duas filhas. Divorciaram-se em 2008 e dividem a custódia das filhas. Louis quase nunca fala sobre suas visões polÃticas, mas há de se notar que defende casamento entre homossexuais.
Primetime Emmy Award for Outstanding Writing for a Variety, Music or Comedy Program (1999)
Indicado – Primetime Emmy Award for Outstanding Writing for a Variety or Music Program (1998)
Indicado – Primetime Emmy Award for Outstanding Writing for a Variety or Music Program (2000)
1998
Tomorrow Night
Homem esguichando as pessoas com mangueira
Direor / Produtor / Roteirista
Indicado – Florida Film Festival Award for Best Narrative
Indicado – Hamptons International Film Festival Award for Best American Independent Film
Grammy Award for Best Comedy Album
The Comedy Award for Stand-up Special
Indicado– Primetime Emmy Award for Outstanding Writing for a Variety, Music Or Comedy Special
Indicado– Primetime Emmy Award for Outstanding Picture Editing for a Special (Single Or Multi-Camera)
Live at the Beacon Theater
Ele mesmo
Stand-up
Primetime Emmy Award for Outstanding Writing for a Variety Special
Indicado – The Comedy Award for Stand-up Special
Indicado – Primetime Emmy Award for Outstanding Special Class Program
Indicado – Primetime Emmy Award for Outstanding Directing for a Variety Special
Indicado – Primetime Emmy Award for Outstanding Picture Editing for Short-Form Segments and Variety Specials
2012–2015
Saturday Night Live
Apresentador
3 episódios
Indicado – Primetime Emmy Award for Outstanding Guest Actor in a Comedy Series (2013–15)
2013
Oh My God
Ele mesmo
Stand-up
American Comedy Award for Comedy Special of the Year
Primetime Emmy Award for Outstanding Writing for a Variety Special
Indicado – Grammy Award for Best Comedy Album
Indicado – Primetime Emmy Award for Outstanding Variety, Music or Comedy Special
Indicado – Primetime Emmy Award for Outstanding Directing for a Variety Special
Indicado – Primetime Emmy Award for Picture Editing for Short-Form Segments and Variety Specials
Blue Jasmine[72]
Al
Indicado – Detroit Film Critics Society Award for Best Ensemble
American Hustle
Stoddard Thorsen
Alliance of Women Film Journalists Award for Best Ensemble Cast
American Comedy Award for Best Comedy Supporting Actor – Film
Critics' Choice Movie Award for Best Acting Ensemble
Detroit Film Critics Society Award for Best Ensemble
New York Film Critics Circle Award for Best Ensemble Cast
Phoenix Film Critics Society Award for Best Cast
Screen Actors Guild Award for Outstanding Performance by a Cast in a Motion Picture
San Diego Film Critics Society Award for Best Performance by an Ensemble
Indicado – Washington D.C. Area Film Critics Association Award for Best Ensemble
Pendente – Screen Actors Guild Award for Outstanding Performance by a Cast in a Motion Picture (Shared withBryan Cranston, Helen Mirren, Michael Stuhlbarg, Diane Lane, Elle Fanning and John Goodman)
↑ abcVogel, Laura (27 de maio de 2007). «Louis C.K.». New York Post. Consultado em 10 de novembro de 2010. Arquivado do original em 25 de abril de 2011