The main event featured TUF 2Heavyweight winner Rashad Evans against TUF 3Light Heavyweight winner Michael Bisping in a light heavyweight contest. This was Bisping's last fight before dropping to Middleweight.[2] Originally, Evans and Bisping were set to rematch their previous opponents Tito Ortiz and Matt Hamill at this event after their bouts ended in a draw and a controversial split decision at UFC 73 and UFC 75. However, Ortiz's commitments to filming Celebrity Apprentice forced his fight with Evans to be cancelled and an injury to Hamill forced him to withdraw from his fight with Bisping.
Additionally, PRIDE veterans Ryo Chonan and Akihiro Gono both made their UFC debuts. Both fighters fought at 183 pounds in Japan, but with the UFC's inclusion of the 170 pound division each fighter moved down to fight at welterweight.