The event was the first the organization hosted in Mexico and was so popular that all 21,000 tickets were sold out in 8 hours.[4]
The event was expected to be headlined by a UFC Heavyweight Championship bout between the current champion Cain Velasquez and top contender Fabrício Werdum.[3] However, on October 21, it was announced that Velasquez was forced to pull out of the bout due to an injured knee and was replaced by Mark Hunt. That also changed the originally planned title fight into an interim title bout.[5]
Norman Parke was expected to face Diego Sanchez at the event. However, Parke pulled out of the bout in early October citing a knee injury and was briefly replaced by Joe Lauzon.[6] In turn, injuries to both Sanchez and Lauzon led to the pairing being scrapped altogether.[7]
Two announced bouts between The Ultimate Fighter: Latin America contestants Masio Fullen vs. Alexander Torres and Fredy Serrano vs. Bentley Syler, previously linked to this event were postponed and will be rescheduled at future events.[10]