A lightweight bout between Matt Frevola and returning veteran Ottman Azaitar was rescheduled for this event.[6] The pairing was previously scheduled to meet in January 2021 at UFC 257, but Azaitar was pulled from the bout and had his contract briefly terminated after it was determined that he had violated COVID-19 health and safety protocols, as he attempted to help others enter the UFC's designated safety zone during fight week.[7]
At the weigh-ins, Ryan Spann and The Ultimate Fighter: Undefeated lightweight winner Michael Trizano missed weight. Spann weighed in at 206.6 pounds, six tenths of a pound over the light heavyweight non-title fight limit. Trizano weighed in at 147.6 pounds, one and six tenths of a pound over the featherweight non-title fight limit. Both bouts proceeded at catchweight with each being fined 20% of their individual purses, which went to their opponents former UFC Light Heavyweight Championship challenger Dominick Reyes and Seung Woo Choi respectively.[8]