TRNASer (uridine44-2'-O)-methyltransferase

TRNASer (uridine^44-2'-O)-methyltransferase
Identifiers
EC no.	2.1.1.211
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

TRNASer (uridine⁴⁴-2'-O)-methyltransferase (EC 2.1.1.211, TRM⁴⁴) is an enzyme with systematic name S-adenosyl-L-methionine:tRNASer (uridine⁴⁴-2'-O)-methyltransferase.^[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + uridine⁴⁴ in tRNASer ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + 2'-O-methyluridine⁴⁴ in tRNASer

The 2'-O-methylation of uridine⁴⁴ contributes to stability of tRNASer(CGA).

References

1. Kotelawala L, Grayhack EJ, Phizicky EM (January 2008). "Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species". RNA. 14 (1): 158–69. doi:10.1261/rna.811008. PMC 2151035. PMID 18025252.

External links

• TRNASer+(uridine44-2'-O)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)