TRNA-uridine aminocarboxypropyltransferase

tRNA-uridine aminocarboxypropyltransferase
Identifiers
EC no.	2.5.1.25
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a tRNA-uridine aminocarboxypropyltransferase (EC 2.5.1.25) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + tRNA uridine ${\displaystyle \rightleftharpoons }$ 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine

Thus, the two substrates of this enzyme are S-adenosyl-L-methionine and tRNA uridine, whereas its two products are 5'-methylthioadenosine and tRNA 3-(3-amino-3-carboxypropyl)-uridine.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase.

References

• Nishimura S, Taya Y, Kuchino Y, Oashi Z (1974). "Enzymatic synthesis of 3-(3-amino-3-carboxypropyl)uridine in Escherichia coli phenylalanine transfer RNA: transfer of the 3-amino-acid-3-carboxypropyl group from S-adenosylmethionine". Biochem. Biophys. Res. Commun. 57 (3): 702–8. doi:10.1016/0006-291X(74)90603-2. PMID 4597321.